Neoplasia — Flashcards

Flashcard 371: Loss of the VHL tumor suppressor gene (renal cell carcinoma) leads to increased _____ transcription factor, which increases VEGF and PDGF

Answer: HIF

Extra:   Watch Renal Cell Carcinoma & Nephroblastoma [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-renal/videos/medical-pathophysiology-renal-renal-cancer-renal-cell-carcinoma-and-nephroblastoma?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/renal?ref=anki Atlas: 

Flashcard 372: One benign cause of a 'coin-lesion' on CXR is _____, which is benign tumor of lung tissue and cartilage

Answer: bronchial hamartoma

Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/pulmonology/videos/lung-cancer?index=4] https://onlinemeded.org/spa/pulmonology/lung-cancer/acquire?ref=anki 

Flashcard 373: Agents that damage DNA are known as _____

Answer: carcinogens

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 374: EBV is associated with _____, the endemic/african form

Answer: Burkitt lymphoma

Extra:   https://onlinemeded.org?ref=anki 

Flashcard 375: Prostatic adenocarcinoma is characterized by small glands that infiltrate normal tissue and nuclei that contain _____

Answer: dark nucleoli

Extra:   Watch Benign Prostatic Hyperplasia (BPH) & Prostate Cancer [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-male-gu-benign-prostatic-hyperplasia-bph-and-prostate-cancer?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/renal/prostate/acquire?ref=anki 

Flashcard 376: _____ implies the cancer is of mesenchymal origin

Answer: Sarcoma

Flashcard 377: Which precursor lesion to penile SCC is more commonly seen in younger patients (40s)? _____

Answer: Bowenoid papulosis

Extra:   * however, bowenoid papulosis rarelly progresses to to SCC Watch Bladder Cancer & Penile Disorders [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-male-gu-bladder-cancer-and-penile-disorders?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org?ref=anki  Linked to HPV, younger patients more likely to have unprotected sex and get HPV 

Flashcard 378: What is the associated tumor that results from translocation 8;14 of the c-MYC oncogene? _____

Answer: Burkitt lymphoma

Extra:   https://onlinemeded.org?ref=anki 

Flashcard 379: A translocation of _____ from chromosome 8 to 14 results in overexpression and ultimately Burkitt lymphoma

Answer: c-MYC

Extra:   https://onlinemeded.org?ref=anki 

Flashcard 380: T-ALL is characterized by lymphoblasts (TdT+) that express markers ranging from CD-_____ to CD-_____

Answer: 2

Extra:   Watch Acute Lymphoblastic Leukemia (ALL), Chronic Lymphocytic Leukemia (CLL), Hairy Cell Leukemia & Adult T cell Leukemia [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-myeloid-lymphoid/videos/medical-pathophysiology-myeloid-and-lymphoid-lymphoid-and-plasma-cell-disorders-acute-lymphoblastic-leukemia-all-chronic-lymphocytic-leukemia-cll-hairy-cell-leukemia-and-adult-t-cell-leukemia?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/leukemias-and-lymphomas?index=4] https://onlinemeded.org/spa/hematology-oncology/leukemia/acquire?ref=anki Other: