Neoplasia — Flashcards

Flashcard 371: Agents that damage DNA are known as _____

Answer: carcinogens

Flashcard 372: The major risk factor for transitional cell carcinoma is _____

Answer: cigarette smoke

Extra: Atlas:

Flashcard 373: Loss of the VHL tumor suppressor gene (renal cell carcinoma) leads to increased _____ transcription factor, which increases VEGF and PDGF

Answer: HIF

Extra: Atlas:

Flashcard 374: Which precursor lesion to penile SCC is more commonly seen in younger patients (40s)? _____

Answer: Bowenoid papulosis

Extra: * however, bowenoid papulosis rarelly progresses to to SCC Linked to HPV, younger patients more likely to have unprotected sex and get HPV

Flashcard 375: EBV is associated with _____, the endemic/african form

Answer: Burkitt lymphoma

Flashcard 376: What is the associated tumor that results from translocation 8;14 of the c-MYC oncogene? _____

Answer: Burkitt lymphoma

Flashcard 377: One benign cause of a 'coin-lesion' on CXR is _____, which is benign tumor of lung tissue and cartilage

Answer: bronchial hamartoma

Flashcard 378: _____ implies the cancer is of mesenchymal origin

Answer: Sarcoma

Flashcard 379: HHV-8 induces _____, resulting in proliferation of vascular endothelial cells

Answer: VEGF

Flashcard 380: A translocation of _____ from chromosome 8 to 14 results in overexpression and ultimately Burkitt lymphoma

Answer: c-MYC