Neoplasia — Flashcards

Flashcard 361: _____ is a neoplastic proliferation of mature myeloid cells, especially platelets

Answer: Essential thrombocythemia (ET)

Extra: Step 2: Other:

Flashcard 362: What is the mechanism that results in malignancy from the ABL oncogene? _____

Answer: t(9;22) with BCR

Extra: * Philadelphia chromosome; rarely associated with ALL

Flashcard 363: In regards to cervical epithelium, a tissue sample showing a mildly increased nuclear-to-cytoplasmic ratio, mild loss of tissue orientation, and cellular pleomorphism is classified as: _____

Answer: Mildly Dysplastic

Flashcard 364: Lung cancer often presents on CXR with a "_____-lesion" or on CT with a non-calcified nodule

Answer: coin

Flashcard 365: Tumor _____ is the degree of localization / spread based on site and size of 1* lesion, spread to regional lymph nodes, and presence of metastases

Answer: stage

Flashcard 366: CML is distinguished from a leukemoid reaction (benign neutrophilia) by presence of increased _____

Answer: basophils

Extra: presence of basophilia and less mature neutrophil precursors (myelocytes > metamyelocytes) favors diagnosis of CML > leukemoid reaction; think of metamyelocyte = more words = more mature Other:

Flashcard 367: Which cutaneous manifestation, Kaposi sarcoma or Bacillary angiomatosis, is associated with lymphocytic infiltrate? _____

Answer: Kaposi sarcoma

Flashcard 368: What is the most common malignancy in the small intestine? _____

Answer: Carcinoid tumor (neuroendocrine cells)

Extra: Refer to endocrine section: Atlas: Other:

Flashcard 369: The intermediate filament Vimentin is found in _____ tissue

Answer: mesenchymal

Flashcard 370: Which precursor lesion to penile SCC is more commonly seen in younger patients (40s)? _____

Answer: Bowenoid papulosis

Extra: * however, bowenoid papulosis rarelly progresses to to SCC Linked to HPV, younger patients more likely to have unprotected sex and get HPV