Neoplasia — Flashcards

Flashcard 1601: _____ is used to characterize tumors that are difficult to classify on histology

Answer: Immunohistochemistry

Flashcard 1602: Reed-Sternberg cells occasionally result in "_____" symptoms (fever, chills, weight loss, night sweats)

Answer: B

Flashcard 1603: Hodgkin's lymphoma _____ type has the most Reed-Sternberg cells

Answer: Lymphocyte depleted

Extra: In Hodgkin lymphoma (HL), the number of Reed-Sternberg (RS) cells is inversely proportional to the number of background lymphocytes: - **Lymphocyte depleted HL**: Most RS cells, worst prognosis. - **Mixed cellularity HL**: Plentiful RS cells. - **Lymphocyte rich HL**: Fewest RS cells, best prognosis.

Flashcard 1604: Dysplastic nevus syndrome is an _____ (inheritance) disorder characterized by formation of dysplastic nevi

Answer: autosomal dominant

Flashcard 1605: _____ radiation is associated with acute myelocytic leukemia

Answer: Ionizing

Flashcard 1606: A _____ is a tumor of pancreatic delta cells

Answer: somatostatinoma

Flashcard 1607: What demographic is most commonly associated with the mucinous carcinoma subtype of invasive ductal carcinoma (breast)? _____

Answer: elderly women (average 70)

Flashcard 1608: _____ of the esophagus is a malignant proliferation of squamous cells

Answer: Squamous cell carcinoma

Flashcard 1609: Patients with _____ have clonal mast cell proliferation in the bone marrow, skin, and other organs

Answer: systemic mastocytosis

Flashcard 1610: Can a **Phyllodes tumor** be malignant?

Answer: Yes, some can be malignant

Extra: Phyllodes tumors are fibroepithelial tumors of the breast characterized by 'leaf-like' architecture and increased stromal cellularity. They are classified as benign, borderline, or malignant. Note: While the tumor itself can be malignant, a history of a benign Phyllodes tumor does not significantly increase the risk of developing future breast carcinomas (unlike lesions like atypical ductal hyperplasia).