Neoplasia — Flashcards

Flashcard 1311: Mycosis fungoides may spread to involve the blood, producing _____ syndrome (T-cell leukemia)

Answer: Sezary

Flashcard 1312: Patients with xeroderma pigmentosum are at risk for which type(s) of skin cancer?

Answer: Basal cell carcinoma, squamous cell carcinoma, and malignant melanoma

Extra: Xeroderma pigmentosum (XP) is an autosomal recessive disorder caused by a defect in nucleotide excision repair (NER), which prevents the repair of pyrimidine dimers formed by UV radiation. This leads to a massive increase in the risk of all major UV-induced skin cancers.

Flashcard 1313: What is the serum tumor marker for hepatocellular carcinoma?_____

Answer: Alpha-fetoprotein, glypican-3, PIVKA

Flashcard 1314: What is the prognosis of medulloblastoma? _____

Answer: Highly malignant (WHO Grade IV), but radiosensitive

Flashcard 1315: What microbe can increase the risk of gastric adenocarcinoma?_____

Answer: H pylori

Flashcard 1316: Squamous cell carcinoma of the cervix, vulva, vagina, anus, and penis are associated with what DNA viruses? _____

Answer: HPV 16, 18, 31, 33

Flashcard 1317: _____ is a malignant tumor of skeletal muscle

Answer: Rhabdomyosarcoma

Flashcard 1318: In rare cases, seminomas may have elevated levels of the hormone _____

Answer: hCG

Flashcard 1319: Mutations in which proto-oncogene can lead to Colon Cancer, Non-Small Cell Lung Adenocarcinoma, and Pancreatic Cancer?_____

Answer: KRAS

Flashcard 1320: Which architectural growth pattern (simple or complex) of endometrial hyperplasia has higher risk of progression to carcinoma?_____

Answer: complex