Neoplasia — Flashcards

Flashcard 121: Histologically, the nuclei of benign tumors are _____, whereas the nuclei of malignant tumors are _____ and hyperchromatic

Answer: uniform

Flashcard 122: Which type of lymphoma is associated with masses composed of lymphoid cells? _____

Answer: Non-Hodgkin lymphoma

Extra: Other:

Flashcard 123: Thyroid follicular adenoma is a benign tumor of follicles surrounded by a(n) _____

Answer: fibrous capsule

Extra: Atlas:

Flashcard 124: Squamous carcinoma in situ is also called _____

Answer: Bowen's disease

Flashcard 125: Sheets of small blue round cells organized around a central space "Homer-Wright rosettes" characterizes histology of _____

Answer: neuroblastomas

Extra: * described as "Homer-Wright" rosettes

Flashcard 126: Renal cell carcinoma is associated with loss of the _____ tumor suppressor gene on chromosome 3p

Answer: VHL

Extra: Atlas:

Flashcard 127: Which salivary gland tumor is associated with a high rate of recurrence following resection? _____

Answer: Pleomorphic adenoma

Extra: Pleomorphic adenoma T2-weighted axial MRI: There is a sharply demarcated, hyperintense, partially lobulated mass arising from the left retromandibular fossa, filling the entire left parapharyngeal space. The lesion is surrounded by a hypointense capsule. This finding is a pleomorphic adenoma. Differential diagnoses include other tumors of the parotid gland. Pleomorphic adenoma Oral cavity of a patient, ventral view: A protrusion of the left lateral wall of the pharynx can be seen. Further diagnostics performed on the patient confirmed a pleomorphic adenoma of the parotid gland, which expanded into the parapharyngeal space. Pleomorphic adenoma of the parotid gland Photomicrograph of parotid gland tissue (H&E stain) On the left, there is a hypercellular area made up of round epithelial cells with hyperchromatic nuclei and narrow, spindle-shaped myoepithelial cells with flattened nuclei. On the right, there is a paucicellular area predominantly made up of hyalinized stroma (pink acellular material). This mixed pattern of epithelial (epithelial and myoepithelial cells) and mesenchymal (stroma) components within a salivary gland tumor is pathognomonic for pleomorphic adenoma. Atlas:

Flashcard 128: Can moles (nevi) transform into melanoma? _____

Answer: Yes

Extra: Atlas:

Flashcard 129: What is the most useful factor in determining prognosis of breast cancer? _____

Answer: Spread to axillary lymph nodes

Flashcard 130: Which tumor suppressor gene is associated with colon cancer? _____

Answer: DCC