Central Nervous System Pharmacology — Flashcards

Flashcard 1: Mechanism of action of sodium valproate: No answer _____

Answer: :)

Flashcard 2: The given plant is? _____

Answer: Erythroxylum cocca

Flashcard 3: tetanospasmin blocks _____

Answer: presynaptic inhibitory neurotransmitter release

Extra: 

Flashcard 4: Non-specific adverse effects associated with carbamazepine include _____ and ataxia

Answer: diplopia

Flashcard 5: Vortioxetine is a _____ receptor antagonist

Answer: 5-HT3

Flashcard 6: The three nonbenzodiazepine hypnotics are _____, Zaleplon, and esZopiclone

Answer: Zolpidem

Flashcard 7: _____ is an investigational glycoengineered monoclonal antibody that targets a unique epitope on CD20-expressing B-cells used in multiple sclerosis

Answer: Ublituximab

Flashcard 8: Neuro/Psych _____ is an anti-epileptic that may be used to treat post-herpetic neuralgia

Answer: Gabapentin

Flashcard 9: Baclofen exerts its effects by _____ of GABAB receptors at the spinal cord level, causing muscle relaxation

Answer: activation

Flashcard 10: Daclizumab is a monoclonal antibody against _____ that is used to treat relapsing multiple sclerosis

Answer: CD25 (part of IL-2 receptor)

Flashcard 11: Valproic acid exerts its effects by increasing _____ channel inactivation and inhibiting GABA transaminase

Answer: Na+

Flashcard 12: Neuro/Psych _____ is an anti-epileptic that may cause GI distress and pancreatitis as adverse effects

Answer: Valproic acid

Flashcard 13: _____ and duetetrabenazine are VMAT-2 inhibitors used in the treatment of Tardive Dyskinesia

Answer: Valbenazine

Flashcard 14: Pharmacologic treatment for fibromyalgia may include anti-_____ or anti-depressants

Answer: convulsants

Flashcard 15: The FDA recently approved _____ for the treatment of partial onset seizures in adult patients with epilepsy

Answer: Cenobamate

Flashcard 16: Neuro/Psych _____ is an anti-epileptic associated with osteopenia (bone complication)

Answer: Phenytoin

Flashcard 17: _____ is a dopamine agonist used in Parkinsons disease as a transdermal patch.

Answer: Rotigotine

Flashcard 18: First Aid Pharmacology: Neuro/Psych _____ is an NMDA receptor antagonist used to treat moderate to severe Alzheimer's disease

Answer: Memantine

Flashcard 19: Neuro/Psych _____ is a peripheral DOPA decarboxylase inhibitor used to increase the bioavailability of levodopa

Answer: Carbidopa

Flashcard 20: benzodiazepines, such as _____ and diazepam, are the 1st-line agents for treatment for acute status epilepticus

Answer: lorazepam

Flashcard 21: Neuro/Psych _____ is a peripheral and central COMT inhibitor used to increase the bioavailability of levodopa

Answer: Tolcapone

Flashcard 22: Natalizumab is a monoclonal antibody against _____ used to treat Multiple Sclerosis and Crohn disease

Answer: 4-integrin

Flashcard 23: Neuro/Psych_____ increase Cl- conductance by increasing the duration of channel opening (frequency or duration)

Answer: Barbiturates

Flashcard 24: Lamotrigine exerts its effects by increasing _____ channel inactivation

Answer: Na+

Flashcard 25: _____ is an NMDA receptor antagonist indicated in refractory primary or secondary generalized seizures and Lennox-Gastaut syndrome.

Answer: Felbamate

Flashcard 26: Antimuscarinic _____ muscarinic antagonists (e.g. Benztropine) can reduce pill rolling tremors and cogwheel rigidity in Parkinson's disease

Answer: M1

Flashcard 27: Neuro/Psych _____ is a 5-HT2 receptor antagonist used to treat serotonin syndrome

Answer: Cyproheptadine

Flashcard 28: Triptans (e.g. sumatriptan) are _____ receptor agonists

Answer: 5-HT1B,D

Flashcard 29: The side effects of ethosuximide may be remembered with the letters of the alphabet "EFGHIJ": E: Ethosuximide F: _____G: GI distressH: HeadacheI: Itching/urticaria J: Steven-Johnson syndrome

Answer: Fatigue

Flashcard 30: Neuro/Psych _____ is an anti-epileptic associated with gingival hyperplasia

Answer: Phenytoin

Flashcard 31: Side effects of metoclopramide include _____ and depression as a result of central D2 blockade

Answer: drowsiness

Flashcard 32: Agonist binding to the MT1 receptor promotes _____ and agonists binding to MT2 receptors shifts the timing of the circadian system.

Answer: the onset of sleep

Flashcard 33: drugs_____ is an 2 agonist that may be used as a muscle relaxant

Answer: Tizanidine

Flashcard 34: Motion sickness (vestibular nausea) is treated with _____ and scopolamine

Answer: 1st generation anti-histamines (diphenhydramine, meclizine)

Flashcard 35: Long-acting _____ are useful in the treatment of alcohol withdrawal (if no cirrhosis or alcoholic hepatitis)

Answer: benzodiazepines

Flashcard 36: Topiramate exerts its effects by increasing _____ channel inactivation

Answer: Na+

Flashcard 37: First Aid Pharmacology: Neuro/Psych_____, nalorphine and nalbuphine are -opioid receptor agonists and weak -opioid receptor antagonists or partial agonists

Answer: Pentazocine

Flashcard 38: _____ is a 5-HT2C agonist indicated as an anti-obesity agent.

Answer: Lorcaserin

Flashcard 39: Management of _____ in Parkinson's treatment includes use of COMT inhibitors or irreversible and reversible MAO-B inhibitors to prolong the ON phase

Answer: On-off phenomenon

Flashcard 40: Trihexyphenidyl and benztropine are useful for treating the _____ and rigidity of Parkinson disease

Answer: tremor

Flashcard 41: First Aid Pharmacology: Neuro/Psych _____ and phenytoin are first-line agents for treatment of acute tonic-clonic seizures

Answer: Valproic acid

Flashcard 42: Neuro/Psych _____ is a non-ergot D2 receptor agonist that is used in initial treatment of Parkinson disease

Answer: Ropinirole

Flashcard 43: Opiate receptor activation causes closure of _____-synaptic Ca2+ channels, which decreases release of neurotransmitters (e.g. ACh, NE, 5-HT, glutamate, substance P)

Answer: pre

Flashcard 44: Phencyclidine (PCP) is a hallucinogen that works primarily as an _____ receptor antagonist

Answer: NMDA

Flashcard 45: Effect of acute ethanol is inhibitory on _____ receptor channels and voltage-gated Ca2+ channels

Answer: NMDA

Flashcard 46: Cocaine exerts its effects via inhibition of the _____ and DAT transporters (reuptake inhibitor)

Answer: NET

Flashcard 47: Calcium channel blockers, such as _____, may be used for migraine prophylaxis

Answer: verapamil

Flashcard 48: Huntington disease may be treated with _____ or reserpine, which inhibit VMAT, decreasing dopamine vesicle packaging and release

Answer: tetrabenazine

Flashcard 49: _____ is a histamine H3-receptor antagonist/inverse agonist indicated for the treatment of narcolepsy with or without cataplexy.

Answer: Pitolisant

Flashcard 50: _____ works in the Renshaw cells of the spinal cord

Answer: Tetanospasmin

Flashcard 51: _____ is a CGRP antagonist approved for migraine

Answer: Telcagepant

Flashcard 52: Neuro/Psych _____ is a non-ergot D3 receptor agonist that is used in initial treatment of Parkinson disease

Answer: Pramipexole

Flashcard 53: Neuro/Psych _____ is an anti-epileptic that exerts its effects by blocking voltage-gated Ca2+ channels

Answer: Gabapentin

Flashcard 54: Opiate receptor activation causes _____ of voltage-gated Ca2+ channels

Answer: closure

Flashcard 55: First Aid Pharmacology: Neuro/Psych_____ is an orexin (hypocretin) receptor antagonist used to treat insomnia

Answer: Suvorexant

Flashcard 56: The _____ receptor antagonism of amantadine is responsible for its antidyskinetic properties in parkinsonism

Answer: NMDA glutamate

Flashcard 57: Management of _____ in Parkinson's treatment includes use of injection apomorphine to shorten the OFF phase

Answer: On-off phenomenon

Flashcard 58: _____ is an analog of carbamazepine that has the advantage of once-daily dosing

Answer: Eslicarbazepine acetate

Flashcard 59: Besides CNS depression, side effects of barbiturates include _____ and respiratory depression, which can be fatal

Answer: cardiac

Flashcard 60: First Aid Pharmacology: Neuro/Psych Adverse effects associated with amantadine include _____ and livedo reticularis

Answer: ataxia

Flashcard 61: Which neurotransmitter's (2) release is inhibited by the Tetanospasmin toxin of Clostridium tetani?_____

Answer: GABA

Flashcard 62: The vestibular system contains _____ histamine receptors, which are coupled to Gq

Answer: H1

Flashcard 63: _____ is a selective 5-HT2A receptor inverse agonist that is approved for the management of delirium and hallucinations associated with Parkinson's disease

Answer: Pimavanserin

Flashcard 64: Antihistamines_____ generation H1 histamine receptor antagonists may be used to treat vestibular nausea and motion sickness

Answer: 1st

Flashcard 65: Neuro/Psych _____ is an SNRI that is indicated for the treatment of fibromyalgia (musculoskeletal pathology)

Answer: Duloxetine

Flashcard 66: Anticonvulsants _____ and brivaracetam act on SV2A proteins and modulates GABA and glutamate release

Answer: Levetiracetam

Flashcard 67: Glatiramer is a treatment for Multiple Sclerosis that is an analog of _____ and works by shifting TH1 cells to a TH2 phenotype

Answer: Myelin Basic Protein

Flashcard 68: The inverse agonist of the _____ receptor is beta-carboline

Answer: benzodiazepine

Flashcard 69: Vilazodone is a _____ receptor partial agonist

Answer: 5-HT1A

Flashcard 70: Neuro/Psych _____ is an anti-epileptic associated with hirsutism in women

Answer: Phenytoin

Flashcard 71: Calcium Channel Blockers (CCBs) _____ is a Ca2+ channel blocker that is used to prevent cerebral vasospasm following a subarachnoid hemorrhage

Answer: Nimodipine

Flashcard 72: Neuro/Psych_____, barbiturates, and alcohol all bind different allosteric sites of the GABAA receptor

Answer: Benzodiazepines

Flashcard 73: _____ is an exotoxin from Clostridium tetani that cleaves SNARE proteins required for neurotransmitter release.

Answer: Tetanospasmin

Flashcard 74: 1st generation H1 receptor antagonists, especially _____, may be used as a sleep aid

Answer: diphenhydramine

Flashcard 75: Vortioxetine is a _____ receptor agonist

Answer: 5-HT1A

Flashcard 76: Neuro/Psych _____ and trihexyphenidyl are antimuscarinic agents used to treat Parkinsonism

Answer: Benztropine

Flashcard 77: Benztropine and trihexyphenidyl primarily affect the _____ (organ system) via inhibition of M1 muscarinic receptors

Answer: CNS

Flashcard 78: As a result of inhibition of VDCCs (N-type Ca2+ channels) located on the _____ membrane of neurons, pregabalin results in decreased neurotransmission

Answer: presynaptic

Flashcard 79: In addition to ethosuximide, absence seizures may also be treated with _____ and lamotrigine

Answer: valproic acid

Flashcard 80: Benzodiazepines are _____ of the GABAA receptor that bind at the / interface of the receptor.

Answer: allosteric modulators

Flashcard 81: _____ is a 5-HT1A partial agonist while vortioxetine is a 5-HT1A agonist/5-HT3 antagonist.

Answer: Vilazodone

Flashcard 82: Neuro/Psych_____ is a competitive antagonist at the benzodiazepine site of the GABA-A receptor, which is used to treat overdose or reverse sedative effects of benzodiazepines AND nonbenzodiazepine hypnotics

Answer: Flumazenil

Flashcard 83: _____ is an anti-epileptic that has hemophagocytic lymphohistiocytosis as a black box warning.

Answer: Lamotrigine

Flashcard 84: Pharmacologic treatment of Idiopathic intracranial hypertension often involves _____ or topiramate

Answer: acetazolamide

Flashcard 85: First Aid Pharmacology: Neuro/Psych _____ and topiramate are anti-epileptics that are useful for migraine prophylaxis

Answer: Valproic acid

Flashcard 86: The symptoms of _____ syndrome can be remembered with the "3 A's": 1. neuromuscular hyperActivity (clonus, hyperreflexia, hypertonia, tremor, seizure) 2. Autonomic stimulation (hyperthermia, diaphoresis, diarrhea)3. Agitation

Answer: serotonin

Flashcard 87: Antihistamines_____ generation H1 receptor antagonists may stimulate appetite and cause weight gain due to anti-serotonergic effects

Answer: 1st

Flashcard 88: The exotoxin _____ inhibits inhibitory neurons, resulting in lack of GABA and Glycine release

Answer: Tetanospasmin

Flashcard 89: Neuro/Psych _____ is the first line treatment for absence seizures

Answer: Ethosuximide

Flashcard 90: _____ generation cephalosporins are able to penetrate the CNS

Answer: 3rd

Flashcard 91: Ramelteon binds the _____ and MT2 receptors in the suprachiasmatic nucleus of the hypothalamus

Answer: MT1

Flashcard 92: Neuro/Psych_____ is a barbiturate used in the acute treatment of partial and tonic-clonic seizures

Answer: Phenobarbital

Flashcard 93: The _____-acting benzodiazepines may be remembered with the mnemonic 'ATOM': A: AlprazolamT: TriazolamO: OxazepamM: Midazolam

Answer: short

Flashcard 94: Neuro/Psych _____ is first line for prophylaxis of status epilepticus

Answer: Phenytoin

Flashcard 95: Neuro/Psych _____ is an anti-epileptic associated with weight loss

Answer: Topiramate

Flashcard 96: First Aid Pharmacology: Neuro/Psych _____ is a treatment for ALS that increases survival by decreasing glutamate excitotoxicity

Answer: Riluzole

Flashcard 97: Neuro/Psych _____ is an anti-epileptic that may cause myopia and acute angle closure glaucoma (eye complications)

Answer: Topiramate

Flashcard 98: Ethosuximide exerts its effects by blocking _____ channels in the thalamus

Answer: T-type Ca2+

Flashcard 99: Neuro/Psych_____ increase Cl- conductance by increasing the frequency of channel opening (frequency or duration)

Answer: Benzodiazepines

Flashcard 100: Opiate receptor activation causes _____ of K+ channels

Answer: opening

Flashcard 101: Local anesthetics exert their actions by blocking _____activated voltage gated Na+ channels (via binding to specific receptors on the inner portion of the channel)

Answer: in

Flashcard 102: _____ is a vasodilator of the inner ear used in the treatment of Meniere's disease

Answer: Betahistine

Flashcard 103: Neuro/Psych_____ is a very weak -opioid receptor agonist that also inhibits 5-HT and norepinephrine reuptake

Answer: Tramadol

Flashcard 104: _____ is a selective non-competitive antagonist of the AMPA-type glutamate receptor.

Answer: Perampanel

Flashcard 105: Neuro/Psych_____ is a melatonin receptor agonist used to treat insomnia especially in transient sleep disorders like jet lag and shift work transition

Answer: Ramelteon

Flashcard 106: Interferon _____ may be used to treat multiple sclerosis

Answer: beta

Flashcard 107: Neuro/Psych _____ is an IV anesthetic that exerts its effect via inhibition of NMDA receptors

Answer: Ketamine

Flashcard 108: Neuro/Psych TCAs, such as _____, may be used for migraine prophylaxis

Answer: amitryptiline

Flashcard 109: _____ is a 5HT2A/2C receptor antagonist indicated in insomnia.

Answer: Ritanserin

Flashcard 110: Neuro/Psych _____ is a peripheral COMT inhibitor used to increase the bioavailability of levodopa

Answer: Entacapone

Flashcard 111: First Aid Pharmacology: Neuro/Psych _____ is a -opioid receptor agonist and -opioid receptor partial agonist

Answer: Butorphanol

Flashcard 112: Drug automatism develops due to the depressant effect of drugs, such as _____ and Alcohol

Answer: CNS Depressants

Flashcard 113: _____ is a nootropic agent (a drug that enhances cognitive function) that is used off-label to enhance memory and to treat myoclonus.

Answer: Piracetam

Flashcard 114: Theophylline may have CNS side effects including _____ and tremor

Answer: nervousness

Flashcard 115: The drug used for refractory intractable rheumatic chorea is _____

Answer: sodium valproate.

Flashcard 116: Which SNRI is contraindicated in closed-angle glaucoma?_____

Answer: Duloxetine

Flashcard 117: Which dopamine receptor agonist is associated with antioxidant effect?_____

Answer: Pramipexole

Flashcard 118: _____ is the first line of management in the treatment of focal seizures.

Answer: Carbamazepine

Flashcard 119: _____ is a benzodiazepine that is also called the date rape drug or roofie.

Answer: Flunitrazepam

Flashcard 120: Local anesthetics can also cause interaction with _____ glutamate receptors

Answer: NMDA 

Flashcard 121: _____ causes dissociative anesthesia.

Answer: Phencyclidine (Drug of abuse)

Flashcard 122: _____ subunit of the GABAA receptors mediate anxiolysis and muscle relaxation

Answer: 2

Flashcard 123: _____ is the drug of choice for myoclonic seizures.

Answer: Sodium valproate

Flashcard 124: What is the name of the sweet made form Bhang?_____

Answer: Majoon

Flashcard 125: Mechanism of action of MgSO4: Blockade of glutaminergic _____ receptors

Answer: NMDA

Flashcard 126: Which IV anesthetic decreases PML chemotaxis, phagocytosis and killing?_____

Answer: Propofol

Flashcard 127: _____ is an 2-agonist used to ameliorate symptoms of opioid withdrawal.

Answer: Lofexidine

Flashcard 128: Methohexital is used as a _____% solution.

Answer: 1

Flashcard 129: Does Naltrexone supress cravings in opioid addiction?_____

Answer: No

Flashcard 130: Which drug recently approved by FDA has free radical scavenging properties and is indicated for ALS?_____

Answer: Edaravone

Flashcard 131: Which drugs should be avoided in alcohol withdrawl delirium as they can reduce the seizure threshold?_____

Answer: Antipsychotics

Flashcard 132: Which reversible MAO-B inhibitor is used for the management of On-off phenomenon in Parkinson's treatment?_____

Answer: Safinamide

Flashcard 133: Which monoclonal antibody is useful for treating migraine?_____

Answer: Fremanezumab

Flashcard 134: Which opiate receptor is associated with lowest abuse potential?_____

Answer: Kappa()

Flashcard 135: Which opiate receptor is associated with diuresis?_____

Answer: Kappa()

Flashcard 136: Mechanism of action of MgSO4: It blocks neuronal _____ influx

Answer: Calcium

Flashcard 137: The "black-outs" associated with high levels of ethanol can be attributed to its action on _____ receptor

Answer: NMDA

Flashcard 138: _____ is a new GABAA receptor agonist, which combines the properties of two unique drugs: Midazolam and remifentanyl

Answer: Remimazolam

Flashcard 139: Levopropoxyphene is a _____ acting opioid antitussive.

Answer: centrally

Flashcard 140: Which tricyclic antidepressant is used for insomnia at lower doses?_____

Answer: Doxepin

Flashcard 141: _____ are a drug of abuse least likely to be associated with seizures

Answer: Cannabinoids

Flashcard 142: Which -vaptan is asssociated with mood and nociception disturbances as an adverse effect?_____

Answer: Nelivaptan

Flashcard 143: N2O is NMDA receptor _____ in the brain

Answer: antagonist

Flashcard 144: _____ is the most potent, most toxic and longest acting local anaesthetic agent

Answer: Dibucaine

Flashcard 145: Which form of cocaine can be smoked?_____

Answer: (-sulphate)

Flashcard 146: _____ (GHB) also called liquid ecstasy is a naturally-occurring neurotransmitter, which acts as a CNS depressant

Answer: -Hydroxybutyrate

Flashcard 147: _____ is an opioid antagonist, with properties similar to those of naloxone.

Answer: Levallorphan

Flashcard 148: Perampanel is associated with the side effect of _____

Answer: suicidal ideation

Flashcard 149: 5HT1A receptor _____ has been found to reduce food intake and hence reduce body weight.

Answer: antagonists

Flashcard 150: Does Strychnine affect brain receptors?_____

Answer: No

Flashcard 151: Less common but more serious side effects such as mood and behavioural changes are associated with _____

Answer: Levetiracetam (Anti-epileptic)

Flashcard 152: Which hallucinogen is associated with violent behavior, nystagmus and hypertension/tachycardia?_____

Answer: PCP

Flashcard 153: _____ blocks Cl- channel noncompetitively.

Answer: Picrotoxin (Plant based toxin)

Flashcard 154: Which antiemetic can be used in levodopa induced emesis?_____

Answer: Domperidone

Flashcard 155: _____ is used in insomnia in blind people, and chronic sleep disorders like non 24-hour sleep wake disorder

Answer: Tasimelteon

Flashcard 156: Which ultra-short acting general anesthetics are associated with histamine release?_____

Answer: Thiopental and Methohexital (2)

Flashcard 157: Rufinamide is an antiepileptic drug used in the treatment of _____ syndrome.

Answer: Lennox- Gastaut

Flashcard 158: _____ is a recently approved drug for treatment of Rett syndrome

Answer: Trofenatide

Flashcard 159: Varenicline is a partial agonist at the _____ receptor

Answer: 42

Flashcard 160: _____ is an inhaled anesthetic associated with the production of nephrotoxic COMPOUND A on interacting with soda lime

Answer: Sevoflurane

Flashcard 161: Use of morphine is contraindicated in head trauma as it can lead to increased _____

Answer: ICP

Flashcard 162: _____ are the most effective group of drugs in the prevention of emergence reactions following ketamine

Answer: Benzodiazepines

Flashcard 163: Affective flattening due to antipsychotics occurs because of their action on _____ receptors

Answer: D2

Flashcard 164: Aducanumab and Lecanemab are anti- _____ monoclonal antibodies used for treatment of Alzheimer's disease

Answer: A

Flashcard 165: Zonisamide is a _____-spectrum antiepileptic

Answer: broad

Flashcard 166: _____ is a partial agonist of 5-HT1A  receptors, used for treatment of hypoactive sexual desire disorder in women

Answer: Flibanserin

Flashcard 167: Which antiepileptic is used in partial seizures due to its ability to act on neuronal potassium channels?_____

Answer: Ezogabine/Retigabine

Flashcard 168: Which nerve fibres are the most susceptible to local anesthetics?_____

Answer: B

Flashcard 169: _____ subunit of the GABAA receptors produces sedation, anterograde amnesia and anticonvulsant action

Answer: 1

Flashcard 170: Which tetracycline is used for short-term improvements in anxiety, mood, and the Clinical Global Impression Scale in Fragile X syndrome?_____

Answer: Minocycline

Flashcard 171: _____ is an IV anesthetic that produces maximum inhibition of airway reflexes

Answer: Propofol

Flashcard 172: Which anti-epileptic drug is responsible for purple glove syndrome (blisters, erythema and discoloration of hands)?_____

Answer: Phenytoin

Flashcard 173: Is Methylprednisolone used for acute attacks or relapsing-remitting type of Multiple sclerosis?_____

Answer: Acute attacks only

Flashcard 174: Which anti-glaucoma drugs can cause drowsiness?_____

Answer: selective alpha-2 agonists

Flashcard 175: Mechanism of action of MgSO4: Reduced presynaptic release of the neurotransmitter _____

Answer: glutamate

Flashcard 176: _____ has an appetite-stimulating effect and has been used to promote weight gain in poor eaters.

Answer: Cyproheptadine

Flashcard 177: The most common side effect of amantadine is minor _____ toxicity

Answer: CNS

Flashcard 178: Lidocaine, Mepivacaine and Prilocaine are _____ acting local anesthetics

Answer: intermediate

Flashcard 179: Which GABA receptor is metabotropic?_____

Answer: GABA B

Flashcard 180: The transdermal patch of the cholinesterase inhibitor _____ is available for use in Alzheimer's disease

Answer: rivastigmine

Flashcard 181: Which anti-epileptic acts by blocking low voltage Na+ channels and T type calcium channels and also has carbonic anhydrase inhibiting activity?_____

Answer: Zonisamide

Flashcard 182: Cocaine inhibits the reuptake of which neurotransmitters?_____

Answer: Dopamine, Norepinephrine and Serotonin

Flashcard 183: Betahistine is a H1 receptor _____ used in Meniere's disease

Answer: agonist

Flashcard 184: Mechanism of action of MgSO4: Potentiation of _____ action

Answer: adenosine (neurotransmitter)

Flashcard 185: Which drugs are pure opioid antagonists?_____

Answer: Naloxone, naltrexone and Nalmefene (3)

Flashcard 186: Which local anesthetic drug has the fastest onset of action?_____

Answer: Mepivacaine

Flashcard 187: The given plant is? _____

Answer: Erythroxylum cocca

Flashcard 188: _____ is the drug of choice for infantile spasms associated with tuberous sclerosis.

Answer: Vigabatrin

Flashcard 189: The best drug for long-term preventive therapy for SUNCT/SUNA is _____.

Answer: lamotrigine

Flashcard 190: _____ is a 5-HT1F receptor agonist used for acute attacks of migraine and can be used in patients with CAD

Answer: Lasmiditan

Flashcard 191: Valproate is _____ used as a first line drug in the treatment of focal seizures with intact awareness

Answer: not

Flashcard 192: Opioids such as meperidine, tramadol, fentanyl and _____ block neuronal uptake of serotonin and can cause Serotonin syndrome

Answer: dextromethorphan

Flashcard 193: _____ is a selective H3 receptor - inverse agonist used in the treatment of Narcolepsy

Answer: Tiprolisant

Flashcard 194: Use of reserpine results in low levels of _____

Answer: dopamine

Flashcard 195: _____ is FDA approved for the treatment of ALS with SOD1 mutation

Answer: Tofersen

Flashcard 196: Vigabatrin acts by irreversibly blocking the _____ to increase GABA action.

Answer: GABA transaminase

Flashcard 197: Which TCA is the drug of choice for post-herpetic neuralgia? _______

Answer: Amitriptyline

Flashcard 198: Drug of choice for attention deficit hyperactivity disorder is:-

Answer: Methylphenidate

Flashcard 199: Drug of choice in treatment of focal complex seizures

Answer: Carbamazepine

Flashcard 200: Drug of choice for petit mal seizures is:

Answer: Ethosuximide

Flashcard 201: Drug of choice for tonic-clonic seizures is ?

Answer: Sodium valproate

Flashcard 202: Drug of choice for relapsing remitting multiple sclerosis is:

Answer: Interferon beta-1a

Flashcard 203: Drug of choice for the initial treatment of parkinsonism -

Answer: Levodopa

Flashcard 204: Drug of choice for treatment of akathisia is:-

Answer: Propranolol

Flashcard 205: Drug of choice for Trigeminal neuralgia is:

Answer: Carbamazepine

Flashcard 206: _______ is the drug of choice for status epilepticus.

Answer: Lorazepam

Flashcard 207: Drug of choice for absence seizures:

Answer: Ethosuximide

Flashcard 208: Drug of choice for drug induced parkinsonism?

Answer: Anticholinergics

Flashcard 209: _______ is the drug of choice for myoclonic seizures.

Answer: Sodium valproate

Flashcard 210: Drug of choice in complex partial seizure is :

Answer: Lamotrigine

Flashcard 211: Drug of choice for essential tremors

Answer: Propranolol

Flashcard 212: Drug of choice in acute severe migraine is:

Answer: Sumatriptan

Flashcard 213: Drug of choice for resistant rheumatic chorea?

Answer: Valproate

Flashcard 214: Drug of choice for juvenile myoclonic epilepsy?

Answer: Valproate

Flashcard 215: Drug of choice for acute severe migraine is

Answer: Triptans

Flashcard 216: Drug of choice for acute severe migraine is:

Answer: Sumatriptan

Flashcard 217: The drug of choice for childhood absence seizures is _______

Answer: Ethosuximide

Flashcard 218: Drug of choice in drug induced parkinsonism is:

Answer: Anticholinergics

Flashcard 219: The treatment of choice for an acute attack of cluster headache is _____

Answer: Sumatriptan at 6 mg subcutaneously

Flashcard 220: Drug of choice for myoclonic seizures is ?

Answer: Valproic acid

Flashcard 221: Drug of choice for Huntington's chorea is

Answer: Haloperidol

Flashcard 222: Drug of choice for Trigeminal neuralgia is :

Answer: Carbamazepine

Flashcard 223: Drug of choice for treatment of Alzheimer's disease is:

Answer: Donepezil