Molecular Biology and Genomics — Flashcards

Flashcard 71: _____ histone tetramer has a central role in the formation of the nucleosome

Answer: (H3H4)2

Flashcard 72: RET proto-oncogene is present on chromosome _____

Answer: 10

Flashcard 73: A _____ is bacteria with plasmids containing DNA fragments representing the majority of the genetic information from a plant or animal.

Answer: genomic library

Flashcard 74: First step of initiation of protein synthesis (translation) involves _____ of the ribosome

Answer: dissociation into subunits

Flashcard 75: _____ is a universal stem cell marker

Answer: ABCG2

Flashcard 76: The generation of diversity in the variable regions of immunoglobulins occurs through _____ gene recombination.

Answer: VDJ

Extra: VDJ recombination is responsible for the assembly of the **variable region** and occurs in the bone marrow (antigen-independent). In contrast, **isotype switching** (class switch recombination) involves the **constant region** and occurs in secondary lymphoid organs like the lymph nodes (antigen-dependent).

Flashcard 77: H1 is _____ tightly bound to chromatin and can be removed by adding salt solution.

Answer: least

Flashcard 78: _____, the 21st amino acid, is coded by the _____ codon by co-translational modification.

Answer: Selenocysteine; UGA

Flashcard 79: The tryptophan operon is a repressible operon that is turned _____ whenever tryptophan is added to the growth medium.

Answer: off

Flashcard 80: HLA genes are _____, located on chromosome _____ inherited from each parent.

Answer: Codominant; Chromosome 6