Transcription Factors and Gene Regulation — Flashcards

Flashcard 1: Which transcriptional factors are important for cardiac hypertrophy?_____

Answer: GATA4, NFAT and MEF2

Flashcard 2: DNA _____ at CpG islands represses transcription

Answer: methylation

Flashcard 3: Histone _____ usually activates DNA transcription

Answer: acetylation

Flashcard 4: Nuclear proteins such as transcription factor _____ are used as limbal stem cell markers

Answer: p63

Flashcard 5: Histone _____ usually reversibly represses DNA transcription

Answer: methylation

Flashcard 6: The gene regulating ovarian and mullerian duct development is _____

Answer: WNT4

Flashcard 7: FISH may be carried out in Metaphase or _____phase of the cell cycle.

Answer: Inter

Flashcard 8: _____ test is a widely used biological assay to assess the mutagenic potential of chemical compounds.

Answer: Ames

Flashcard 9: There are approximately _____ genes present in the human genome.

Answer: 20,000-25,000

Extra: The number of protein-coding genes in the human genome was initially estimated by the Human Genome Project to be around 30,000-40,000, but has since been refined to approximately 20,000-25,000.