Autonomic/CV Drugs — Flashcards

Flashcard 2021: Flushing and warmth, secondary to niacin use, may be prevented with _____

Answer: NSAIDs

Flashcard 2022: What drug intoxication presents as emotional lability, slurred speech, ataxia, and blackouts? _____

Answer: Alcohol

Flashcard 2023: Loop diuretics cause _____ hypertonicity of the renal medulla (increased or decreased)

Answer: decreased

Flashcard 2024: Which NSAID has reduced risk of ulcers and bleeding? _____

Answer: Celecoxib

Flashcard 2025: Which antitumor monoclonal antibody targets vascular endothelial growth factor?_____

Answer: bevacizumab

Flashcard 2026: Cocaine may induce coronary _____, which can cause myocardial ischemia and Prinzmetal angina

Answer: vasospasm

Flashcard 2027: **Methotrexate** must be monitored with LFTs because chronic use increases the risk of hepatic fibrosis and _____.

Answer: cirrhosis (hepatic fibrosis)

Extra: Methotrexate is a folate antagonist (inhibits dihydrofolate reductase) used for rheumatoid arthritis, psoriasis, and certain malignancies. Chronic use is associated with hepatotoxicity, specifically the development of hepatic fibrosis and cirrhosis, which necessitates periodic monitoring of liver function tests (LFTs). It is also associated with myelosuppression and pulmonary fibrosis.

Flashcard 2028: The Jod-Basedow phenomenon is seen nosocomially after administration of iodine _____

Answer: IV contrast

Flashcard 2029: Cilostazol causes coronary artery vasodilation, which may result in _____ syndrome

Answer: coronary steal

Flashcard 2030: Sulfonylureas and meglitinides have significant risk of causing _____ as a possible side effect

Answer: hypoglycemia