Systemic Pathology — Flashcards

Flashcard 971: The antibody-bound platelets in ITP are consumed by _____, resulting in thrombocytopenia

Answer: splenic macrophages

Flashcard 972: _____ renal cysts are very common and account for majority of all renal masses; typically asymptomatic

Answer: Simple

Flashcard 973: Is Primary Myelofibrosis associated with JAK2 mutations?

Answer: Yes (approximately 50-60% of cases)

Flashcard 974: Which cause of genital ulceration presents with donovan bodies on biopsy?_____

Answer: Granuloma inguinale/donovanosis (Klebsiella granulomatis)

Flashcard 975: One hematological pathology that is due to abnormal splicing variants is _____

Answer: β-thalassemia

Extra: β-thalassemia is often caused by point mutations in promoter sequences or **splice sites** (leading to abnormal splicing variants). In contrast, α-thalassemia is primarily caused by gene deletions.

Flashcard 976: The hyperfiltration in diabetic glomerulonephropathy can lead to eosinophilic nodular glomerulosclerosis, known as _____ nodules

Answer: Kimmelstiel-Wilson

Flashcard 977: Which developmental pathology is characterized by bronchiectasis, recurrent sinusitis, and situs inversus? _____

Answer: Kartagener syndrome

Flashcard 978: Vitamin D deficiency causes _____ in adults; presents as bone pain, muscle weakness

Answer: osteomalacia

Flashcard 979: Which types of amyloidosis deposit systemically? _____

Answer: Primary (AL) and secondary (AA)

Flashcard 980: Osteogenesis imperfecta may present with _____ due to abnormal ossicles

Answer: hearing loss