Systemic Pathology — Flashcards

Flashcard 961: Which blistering skin disorder is characterized histologically by detachment of the basal cell layer from the basement membrane? _____

Answer: Bullous pemphigoid

Flashcard 962: Hereditary spherocytosis is most often inherited in an _____ pattern

Answer: autosomal dominant

Flashcard 963: Chronic osteomyelitis may be seen on X-ray as a _____ focus of bone destruction containing a sequestrum (necrotic bone) and surrounded by an involucrum (new bone).

Answer: lytic

Flashcard 964: What spinal cord level is most commonly affected by poliovirus? _____

Answer: Lumbar levels

Flashcard 965: Acute tubular necrosis may be caused by high levels of _____ (e.g. tumor lysis syndrome)

Answer: uric acid

Flashcard 966: Proteus mirabilis is a gram negative bacteria that classically forms large, _____ (form from struvite stones) in the renal pelvis

Answer: 'staghorn' calculi

Flashcard 967: The antibody-bound platelets in ITP are consumed by _____, resulting in thrombocytopenia

Answer: splenic macrophages

Flashcard 968: Which cause of genital ulceration presents with donovan bodies on biopsy?_____

Answer: Granuloma inguinale/donovanosis (Klebsiella granulomatis)

Flashcard 969: The hyperfiltration in diabetic glomerulonephropathy can lead to eosinophilic nodular glomerulosclerosis, known as _____ nodules

Answer: Kimmelstiel-Wilson

Flashcard 970: One hematological pathology that is due to abnormal splicing variants is _____

Answer: β-thalassemia

Extra: β-thalassemia is often caused by point mutations in promoter sequences or **splice sites** (leading to abnormal splicing variants). In contrast, α-thalassemia is primarily caused by gene deletions.