Neoplasia — Flashcards

Flashcard 761: Pancreatic adenocarcinoma is a very aggressive tumor arising from the pancreatic _____

Answer: ducts

Extra: Atlas:

Flashcard 762: _____ is the malignant proliferation of prostatic glands

Answer: Prostate adenocarcinoma

Flashcard 763: The tumor cells of pilocytic astrocytomas stain positive for _____

Answer: GFAP

Extra: * BRAF mutation leads to autoactivation of abnormal Atlas:

Flashcard 764: Diagnosis of Multiple myeloma is confirmed by bone marrow biopsy showing _____

Answer: > 10% clonal plasma cells

Extra: * LPL bone marrow biopsy shows > 10% neoplastic cells (down below)

Flashcard 765: Diffuse Large B-Cell Lymphoma is most commonly caused by alterations in _____ or Bcl-6

Answer: Bcl-2

Extra: - Bcl-2 helps stabilize the outer mitochondrial membrane, preventing efflux of pro-apoptotic proteins - Bcl-6 is a repressor of transcription that helps regulate the IL-4 responses of B-cells, and helps lead the differentiation of naive helper T cells in follicular helper T cells

Flashcard 766: _____ is a renal hamartoma comprised of blood vessels, smooth muscle, and adipose tissues

Answer: Angiomyolipoma

Extra: The last A in the mnemonic HAMARTOMAS to help remember Tuberous sclerosis Atlas:

Flashcard 767: Glioblastomas are most common in the _____ lobes

Answer: frontal and temporal

Flashcard 768: Which skin cancer presents as a "pink, pearl-like papule" with telangiectasias? _____

Answer: Basal cell carcinoma

Extra: Atlas:

Flashcard 769: What is the mechanism that results in malignancy from the KIT oncogene? _____

Answer: point mutation

Flashcard 770: Patients with granulosa cell tumors can develop a(n) _____ carcinoma

Answer: endometrial

Extra: * May also cause precocious puberty and irregular menses