Neoplasia US Medical PG Flashcards - Medical Study Cards
Master Neoplasia with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Neoplasia Flashcard Deck - 10 Cards
Flashcard 581: Grossly, mesothelioma most commonly presents with nodular / smooth pleural _____
Answer: thickening
Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/pulmonology/videos/lung-cancer?index=8]
https://onlinemeded.org?ref=anki
Flashcard 582: A(n) _____ of function mutation to a tumor suppressor gene increases the risk of cancer
Answer: loss
Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/pathology/videos/cellular-injury-and-neoplasia?index=10]
https://onlinemeded.org?ref=anki
Flashcard 583: Chronic Myeloid Leukemia may progress to "_____", which is characterized by a rapid production of blasts (>20%)
Answer: blast crisis
Extra: Watch Acute Myeloid Leukemia (AML) & Chronic Myeloid Leukemia (CML) on Sketchy Medical.
Flashcard 584: _____ tumors usually display minimal mitotic activity
Answer: Benign
Extra:
https://onlinemeded.org?ref=anki
Flashcard 585: Most notably, the serum tumor marker CA 19-9 is seen elevated in _____
Answer: Pancreatic Adenocarcinoma
Extra:
https://onlinemeded.org/spa/gastroenterology/esophagus/acquire?ref=anki
Flashcard 586: Asbestos acts as a carcinogen by physically destroying cellular _____
Answer: chromosomes
Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/pulmonology/videos/restrictive-lung-disease?index=6]
https://onlinemeded.org?ref=anki
Flashcard 587: _____ is a malignant cartilage-forming tumor
Answer: Chondrosarcoma
Extra:
* Grade determines biological behavior; Male (3): Female (1) ratio
Watch Malignant Bone Tumors [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-musculoskeletal-derm/videos/medical-pathophysiology-musculoskeletal-and-derm-bone-malignant-bone-tumors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
https://onlinemeded.org/spa/endocrine/bone-tumors/acquire?ref=anki
Atlas:
Flashcard 588: _____ is a neoplastic proliferation of Langerhans cells
Answer: Langerhans cell histiocytosis
Extra:
https://onlinemeded.org/spa/hematology-oncology/lymphoma/acquire?ref=anki
Other:
Flashcard 589: _____-sided colorectal carcinoma usually arises as a result of the microsatellite instability pathway
Answer: Right
Extra:
https://onlinemeded.org/spa/gastroenterology/colon-cancer/acquire?ref=anki
Colorectal carcinogenesis pathways
Top: Chromosomal instability pathway (adenoma-carcinoma sequence)
- Loss of the tumor suppressor gene, APC, results in hyperproliferative epithelium due to a loss of cellular adhesion and increased cellular proliferation. A mutation in KRAS results in unregulated cellular signaling and cellular proliferation, leading to the formation of an adenoma. Loss of the tumor suppressor genes TP53 and DCC results in the malignant transformation of an adenoma to carcinoma. The chromosomal instability pathway is responsible for carcinomas in FAP (loss of APC) as well as in most cases of sporadic colorectal carcinoma.
Bottom: Microsatellite instability pathway
- Acquired or inherited mutations in the mismatch repair genes (esp. MLH1 and MSH2) result in abnormal proliferation and the formation of adenoma and carcinoma. The microsatellite instability pathway is responsible for carcinomas in Lynch syndrome (HNPCC) and a few cases of sporadic colorectal carcinoma.
Atlas:
Flashcard 590: Mesothelioma is almost always positive for calretinin and _____
Answer: cytokeratin 5/6
Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/pulmonology/videos/lung-cancer?index=8]
https://onlinemeded.org?ref=anki
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