Neoplasia — Flashcards

Flashcard 531: Transformation of CLL into diffuse, large B-cell lymphoma presents clinically as a(n) _____ lymph node or spleen

Answer: enlarging

Extra: Other:

Flashcard 532: _____ is a benign papillary tumor of the vocal cord

Answer: Laryngeal papilloma

Flashcard 533: Which skin cancer typically presents as an elevated nodule with telangiectasias, rolled borders, central crusting, and/or ulcerations? _____

Answer: Basal cell carcinoma (nodular type)

Extra: Atlas:

Flashcard 534: Polycythemia vera is a form of _____ polycythemia

Answer: primary

Flashcard 535: Which type of UV light increases risk of skin cancer? _____

Answer: Both UVA and UVB :)

Flashcard 536: Ependymomas are CNS tumors characterized histologically by _____

Answer: perivascular pseudorosettes

Extra: * rod-shaped blepharoblasts (basal ciliary bodies) also found near nucleus Ependymal pseudorosette Photomicrograph of brain tissue (H&E stain) Tumor cells (cylindrical epithelium) are arranged in a radial manner around several vessels. This pattern is called a perivascular pseudorosette. Perivascular pseudorosettes are a hallmark of ependymoma. Ependymoma Photomicrograph of ependymal tissue (H&E stain) There is an abnormally high number of cells with round nuclei and abundant cytoplasms. Some cells are arranged in a spoke-and-wheel pattern, surrounding an empty central lumen. Such patterns are called ependymal rosettes (example indicated by green overlay). Other cells are arranged concentrically around vessels, producing a similar appearance (perivascular pseudorosettes; example indicated yellow overlay). Ependymoma Cranial MRI (FLAIR-sequence, sagittal view) A hyperintense, heterogeneous, extended mass is visible on the roof of the 4th ventricle (white outline). At the superior aspect of the tumor, multiple cysts are present (white arrows). As a result of an obstructed circulation of the cerebrospinal fluid, the 3rd ventricle appears widened. This is a typical radiologic presentation and location of ependymoma. Atlas:

Flashcard 537: CML may transform to acute _____ leukemia (1/3rd of transformations)

Answer: lymphoid

Extra: Other:

Flashcard 538: The blasts seen in acute leukemia are large, immature cells, often with "punched out" _____

Answer: nucleoli

Extra: Other:

Flashcard 539: In Burkitt lymphoma, the _____ B cells are due to a product of gene translocation

Answer: aggressive

Extra: * translocation between chromosome 8 & 14

Flashcard 540: _____ is a neoplastic proliferation of mature myeloid cells, especially megakaryocytes

Answer: Myelofibrosis

Extra: Atlas: Other: