Neoplasia US Medical PG Flashcards - Medical Study Cards
Master Neoplasia with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Neoplasia Flashcard Deck - 10 Cards
Flashcard 261: Which of the following types of tumors invade locally and have the potential to metastasize?
_____
Answer: Malignant
Extra:
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Flashcard 262: Is medulloblastoma typically seen in adults or children?
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Answer: Children
Extra:
Watch Pediatric CNS Tumors [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-neuro/videos/medical-pathophysiology-neuro-intracranial-hypertension-and-tumors-pediatric-cns-tumors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/neurology/videos/pediatric-brain-tumors?index=4]
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Medulloblastoma
T2-weighted cranial MRI (axial view) of a 7-year-old boy: isodense round lesion with hyperintense sections in the fourth ventricle (green overlay); grossly diminished gyration of the cerebellum (C). (P = poorly demarcated pons region; B = basilar artery, CS = external CSF space)
Medulloblastoma
T1-weighed cranial MRI of a 6-year-old child presenting with features of increased intracranial pressure (midsagittal section with contrast)
There is a large hypointense mass occupying the third (upper yellow overlay) and fourth (lower yellow overlay) ventricles that is causing obstructive hydrocephalus (pink overlay).
The pink overlay also highlights the leakage of CSF into the periventricular space (transependymal edema) and into the occipital lobe due to the increased intraventricular pressure.
This appearance of a fourth ventricular mass in a child is characteristic of medulloblastoma.
Medulloblastoma
Cranial MRI (T1-weighted, with contrast)
There is a mass in the posterior cranial fossa. It features solid parts (green overlay) and cystic parts (red overlay).
Location and appearance are typical of a medulloblastoma.
(D: diencephalon; P: pons; C: cerebellum; yellow outline: cerebellar tentorium)
Medulloblastoma
Photomicrograph of cerebellar vermis tissue (H&E stain)
Densely packed, small, blue anaplastic cells are present throughout the specimen. The cells have pleomorphic and hyperchromatic nuclei.
On the right, a vessel (its lumen mostly obstructed by eosinophilic material) can be seen.
These are typical histopathological findings of medulloblastoma.
Medulloblastoma
Photomicrograph of cerebellar vermis tissue (H&E stain)
Numerous small, blue, round cells with scant cytoplasm can be seen throughout the specimen (classic examples: arrows, green overlay). Their nuclei vary in size and structure (nuclear pleomorphism) and many cells feature distinctly hyperchromatic nuclei.
The majority of the cells are arranged in concentric clusters around lighter central areas consisting of neuropil (examples: dashed outlines and yellow overlay, magnified area). These clusters are referred to as Homer Wright rosettes.
These histopathological features, particularly the Homer Wright rosettes, are characteristic of a medulloblastoma.
Atlas:
Flashcard 263: What is the major risk factor for basal cell carcinoma?
_____
Answer: UV-B light
Extra:
Watch Actinic Keratosis, Squamous Cell Carcinoma & Basal Cell Carcinoma [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-musculoskeletal-derm/videos/medical-pathophysiology-musculoskeletal-and-derm-derm-actinic-keratosis-squamous-cell-carcinoma-and-basal-cell-carcinoma?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/dermatology/videos/malignant-skin-disorders?index=2]
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Atlas:
Flashcard 264: In addition to 'Orphan Annie eye' nuclei, thyroid papillary carcinoma may have cells with intranuclear _____ and inclusions
Answer: grooves
Extra:
* nuclei with central clearing, sometimes described as "ground glass" nuclei
Watch Thyroid Nodules & Cancer [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-endocrine/videos/medical-pathophysiology-endocrine-thyroid-and-parathyroid-thyroid-nodules-and-cancer?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
https://onlinemeded.org/spa/endocrinology/thyroid/acquire?ref=anki
Atlas:
Flashcard 265: An exophytic mass with bleeding and ulcerations is the characteristic gross appearance of _____-type gastric adenocarcinoma
Answer: intestinal
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Flashcard 266: Striated muscle can give rise to a(n) _____ (benign) and rhabdomyosarcoma (malignant)
Answer: rhabdomyoma
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Flashcard 267: What nonkeratinized squamous cell malignancy of the anus arises near the dentate/pectinate line?
_____
Answer: Basaloid carcinoma
Extra:
Watch Anorectal Disorders [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-gi/videos/medical-pathophysiology-gi-colorectal-and-anal-disorders-anorectal-disorders?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch associated Bootcamp video [https://app.bootcamp.com/med-school/dermatology/videos/malignant-skin-disorders?index=2]
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Flashcard 268: Lobular carcinoma in situ (LCIS) is often discovered _____; does not produce mass or calcification
Answer: incidentally
Extra:
Watch Breast Cancer [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-breast-breast-cancer?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
https://onlinemeded.org/spa/surgery-general/breast-cancer/acquire?ref=anki
Flashcard 269: _____ is a malignant germ cell tumor composed of mononuclear cytotrophoblasts and multinuclear syncytiotrophoblasts, but with absent villi
Answer: Choriocarcinoma
Extra:
Watch Hydatidiform Mole & Choriocarcinoma [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-gestational-disorders-hydatidiform-mole-and-choriocarcinoma?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
Watch Testicular Disorders & Cancer [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-gestational-disorders-hydatidiform-mole-and-choriocarcinoma?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
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Flashcard 270: Testicular germ cell tumors that are _____ (43%) have variable responses to radiotherapy and metastasize _____
Answer: non-seminomas
Extra:
* e.g. teratomas & yolk sac (endodermal sinus) tumors
Watch Testicular Disorders & Cancer [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-male-gu-testicular-disorders-and-cancer?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
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