Neoplasia — Flashcards

Flashcard 211: Is a Hamartoma neoplastic? _____

Answer: No

Flashcard 212: Breast Cancer Assessment: _____ is a receptor located on the cell membrane.

Answer: HER-2 (c-erbB2)

Extra: HER2/neu (c-erbB2) is a receptor tyrosine kinase. Overexpression is assessed via immunohistochemistry (IHC) or FISH.

Flashcard 213: Hodgkin lymphomas stem from a mutated _____ in the germinal center or shortly after leaving the germinal center resulting in a proliferation of clonal _____ cells

Answer: B lymphocyte

Flashcard 214: Waldeyer's Ring is lymphoid tissue in the pharynx that is often involved in _____

Answer: non-Hodgkin's lymphoma

Flashcard 215: Which tumor suppressor gene is associated with pancreatic cancer? _____

Answer: DPC4/SMAD4

Flashcard 216: _____ tumor is a testicular sex cord stromal tumor comprised of tubules, usually clinically silent

Answer: Sertoli cell

Flashcard 217: What histological finding may be associated with mesothelioma? _____

Answer: Psammoma bodies

Flashcard 218: Mutations in which tumor suppressor gene can lead to Melanoma, Pancreatic Cancer, and Dysplastic Nevus Syndrome? _____

Answer: CDKN2A

Flashcard 219: What microbe can increase the risk of gastric MALT lymphoma? _____

Answer: H pylori

Flashcard 220: Leydig cell tumor is a sex cord-stromal tumor associated with characteristic _____ (eosinophilic cytoplasmic inclusion) on histology

Answer: Reinke crystals

Extra: Hedwig (Leydig) is made of rank crystals (reinke crystal)