Neoplasia — Flashcards

Flashcard 171: Mycosis fungoides typically presents in adults with _____ patches/plaques

Answer: skin

Extra: Atlas: Other:

Flashcard 172: Which architectural growth pattern of endometrial hyperplasia has higher risk of progression to carcinoma? _____

Answer: Complex

Flashcard 173: The typical ratio of kappa to lambda immunoglobulin light chain phenotypes is _____:_____

Answer: 3

Flashcard 174: _____ commonly arise from the proximal femur, pelvis and hip

Answer: Chondrosarcomas

Flashcard 175: Plasma cell dyscrasias are characterized by the production of _____

Answer: monoclonal immunoglobulin ("M protein")

Extra: Plasma cell dyscrasias (e.g., multiple myeloma, MGUS) are a group of disorders involving the neoplastic proliferation of a single clone of plasma cells. This leads to the production of a monoclonal immunoglobulin or light chain, known as the M protein (monoclonal protein).

Flashcard 176: Which type(s) of cells line the fibrovascular projections of an intraductal papilloma of the breast? _____

Answer: Both epithelial (luminal) and myoepithelial cells

Flashcard 177: B-ALL with t(12;21) has a(n) _____ prognosis and is more commonly seen in children

Answer: good

Extra: Other:

Flashcard 178: Risk factors for squamous cell carcinoma of skin include _____ therapy, arsenic poisoning, and chronic inflammation (e.g. draining sinus tract)

Answer: immunosuppressive

Extra: Atlas:

Flashcard 179: Which tumor suppressor gene is associated with familial adenomatous polyposis (FAP) and colorectal cancer? _____

Answer: APC

Flashcard 180: The Knudson two-hit hypothesis states that _____ copy/copies of a tumor suppressor gene must be knocked out for tumor formation

Answer: both