Neoplasia — Flashcards

Flashcard 1661: Osteosarcoma typically presents as a pathologic _____ or bone pain with swelling

Answer: fracture

Flashcard 1662: What is the relative risk of developing invasive breast carcinoma with atypical epithelial hyperplasia (fibrocystic changes)? _____

Answer: 5x increased risk

Flashcard 1663: Where do mantle cell lymphomas occur?_____

Answer: Mantle zone of the lymph node

Flashcard 1664: Which CNS tumor is characterized histologically by "pseudopalisading" necrosis?

Answer: Glioblastoma multiforme (GBM)

Flashcard 1665: The _____ variant of papillary thyroid cancer is characterized by cells whose height is at least twice their width.

Answer: Tall cell variant

Extra: Tall cell variant is a more aggressive subtype of papillary thyroid carcinoma, often seen in older individuals and associated with higher rates of vascular invasion and extrathyroidal extension. The cells are characterized by abundant eosinophilic cytoplasm and a height that is at least twice (some sources say thrice) their width.

Flashcard 1666: What is the cancer risk associated with HPV16?_____

Answer: High

Flashcard 1667: One subtype of invasive ductal carcinoma (breast) is _____ carcinoma, which produces tubules in a desmoplastic stroma

Answer: tubular

Flashcard 1668: How many cellular divisions occur before the earliest clinical symptoms of cancer arise?_____

Answer: About 30

Flashcard 1669: _____ radiation is associated with papillary carcinoma of the thyroid

Answer: Ionizing

Flashcard 1670: Vinyl Chloride is a carcinogen associated with what type of cancer? _____

Answer: Angiosarcoma of the Liver