Neoplasia — Flashcards

Flashcard 1001: Polycythemia vera is a form of _____ polycythemia (primary or secondary)

Answer: primary

Flashcard 1002: Osteoblastoma presents with bone pain that _____ resolve with aspirin

Answer: DOES NOT

Flashcard 1003: Which cartilage tumor arises in the medulla of the small bones in the hands and feet?

Answer: Enchondroma

Flashcard 1004: EBV can result in _____ carcinoma, especially in Asian and African males

Answer: nasopharyngeal

Flashcard 1005: Is essential thrombocythemia (ET) associated with JAK2 mutations? What other mutations are commonly involved?

Answer: Yes (~50-60%). It is also associated with **CALR** (calreticulin) and **MPL** mutations.

Extra: Approximately 10-15% of patients with Essential Thrombocythemia are "triple-negative," meaning they lack JAK2, CALR, and MPL mutations.

Flashcard 1006: What is the most common cause of death in multiple myeloma? _____

Answer: Infection

Flashcard 1007: Extragonadal germ cell tumors arise in _____ locations

Answer: midline

Flashcard 1008: Which tumor suppressor gene is associated with breast, prostate and endometrial cancer?_____

Answer: PTEN

Flashcard 1009: Which bone tumor is associated with a "soap-bubble" appearance on X-ray? _____

Answer: Giant cell tumor

Flashcard 1010: Transitional cell (urothelial) carcinoma tumors are often multifocal and recur due to a "_____ defect"

Answer: field