Neoplasia — Flashcards

Flashcard 1001: What malignancy is associated with Paget disease of bone (osteitis deformans)? _____

Answer: Osteosarcoma

Flashcard 1002: Ewing sarcoma is associated with an "_____" appearance on X-ray

Answer: onion-skin

Flashcard 1003: Imaging of osteoid osteoma reveals a bony mass, _____ 2 cm, with a radiolucent core (osteoid)

Answer: <

Flashcard 1004: What is the most common type of breast cancer? _____

Answer: Invasive ductal carcinoma (~75% of all breast cancers)

Flashcard 1005: Which cartilage tumor arises in the medulla of the small bones in the hands and feet?

Answer: Enchondroma

Flashcard 1006: Extragonadal germ cell tumors arise in _____ locations

Answer: midline

Flashcard 1007: The t(9;22) translocation (BCR-ABL) is also known as the _____ chromosome

Answer: Philadelphia

Flashcard 1008: EBV can result in _____ carcinoma, especially in Asian and African males

Answer: nasopharyngeal

Flashcard 1009: Is essential thrombocythemia (ET) associated with JAK2 mutations? What other mutations are commonly involved?

Answer: Yes (~50-60%). It is also associated with **CALR** (calreticulin) and **MPL** mutations.

Extra: Approximately 10-15% of patients with Essential Thrombocythemia are "triple-negative," meaning they lack JAK2, CALR, and MPL mutations.

Flashcard 1010: Osteoblastoma is a benign tumor of osteoblasts, typically _____ 2 cm in size.

Answer: > (Greater than) 2 cm

Extra: Osteoid osteoma is a similar benign tumor of osteoblasts but is characteristically < 2 cm in size and presents with pain that is relieved by aspirin. Osteoblastoma is > 2 cm and the pain is typically not relieved by aspirin.