Pharmacokinetics and Pharmacodynamics — Flashcards

Flashcard 111: How is heparin metabolised in the body?_____

Answer: Cleared by the RES

Flashcard 112: Rocuronium, vecuronium, and rapacuronium are primarily dependent on the _____ for elimination.

Answer: Liver (biliary excretion)

Extra: Pancuronium is primarily eliminated by the kidneys (approx. 80%). Atracurium and cisatracurium undergo Hofmann elimination (spontaneous degradation in plasma independent of organ function). Rocuronium and vecuronium are the primary aminosteroid blockers that depend on hepatic clearance.

Flashcard 113: What is the mechanism of action of Aconite?_____

Answer: stimulation of voltage sensitive sodium channels

Flashcard 114: Which "-flurane" drug undergoes minimum metabolism by our body?_____

Answer: Desflurane

Flashcard 115: Systemic absorption of a local anesthetic depends on _____ of the region

Answer: vascularity

Flashcard 116: Which fluoroquinolones have the maximum bioavailability?_____

Answer: Levofloxacin and ofloxacin

Flashcard 117: What is the inhaled anesthetic with the highest solubility/Blood-Gas coefficient (slowest induction)?_____

Answer: Halothane

Flashcard 118: Which opioid has maximum plasma protein binding?_____

Answer: Sufentanil

Flashcard 119: Succinylcholine and mivacurium are metabolized by the enzyme _____

Answer: pseudocholinesterase

Flashcard 120: Cabergoline is a _____-acting D2 agonist

Answer: longer