Pharmacokinetics and Pharmacodynamics — Flashcards

Flashcard 121: The duration of action of proparacaine is approximately _____ minutes.

Answer: 10-20

Flashcard 122: Loading dose is essential for chloroquine because of its property of _____

Answer: high Vd

Flashcard 123: Meyer Overton rule relates potency of an anesthetic to the solubility in _____

Answer: lipid

Flashcard 124: _____ should be taken on an empty stomach because food decreases the absorption.

Answer: Rifampicin (Anti-tubercular drug)

Flashcard 125: The _____ of plasma concentration vs. time curve gives the extent of absorption.

Answer: AUC

Flashcard 126: Half life of methylprednisolone is _____ that of prednisolone.

Answer: equal

Flashcard 127: Pancuronium and d-tubocurarine can_____ be administered in patients with _____ failure

Answer: not; renal

Flashcard 128: The nomogram used for vancomycin dosing is the _____ nomogram.

Answer: Matzke

Flashcard 129: When the rate of drug **administration** equals the rate of drug **elimination**, the drug has reached _____ concentration.

Answer: Steady-state concentration (Css)

Extra: Steady-state is achieved when the rate of drug administration (input) equals the rate of drug elimination (output). It typically takes 4–5 half-lives (t½) to reach steady-state. Formula for IV infusion: $Css = \frac{Rate\ of\ infusion}{Clearance}$

Flashcard 130: The plasma half-life of beta hCG is _____ hours.

Answer: 36