Pharmacokinetics and Pharmacodynamics — Flashcards

Flashcard 121: Succinylcholine and mivacurium are metabolized by the enzyme _____

Answer: pseudocholinesterase

Flashcard 122: Meyer Overton rule relates potency of an anesthetic to the solubility in _____

Answer: lipid

Flashcard 123: _____ should be taken on an empty stomach because food decreases the absorption.

Answer: Rifampicin (Anti-tubercular drug)

Flashcard 124: Loading dose is essential for chloroquine because of its property of _____

Answer: high Vd

Flashcard 125: Itraconazole is a drug with _____ pKa and requires the acidity of the stomach for its absorption into the circulation.

Answer: low

Flashcard 126: _____ can be safely used in renal failure patients.

Answer: Remifentanil::Opioid

Flashcard 127: If a drug has _____ renal clearance than GFR, then drug is secreted in renal tubules.

Answer: more::more/less

Flashcard 128: _____ is a monoclonal antibody that inhibits B lymphocyte stimulator

Answer: Belimumab

Flashcard 129: Half life of methylprednisolone is _____ that of prednisolone.

Answer: equal

Flashcard 130: When the rate of drug **administration** equals the rate of drug **elimination**, the drug has reached _____ concentration.

Answer: Steady-state concentration (Css)

Extra: Steady-state is achieved when the rate of drug administration (input) equals the rate of drug elimination (output). It typically takes 4–5 half-lives (t½) to reach steady-state. Formula for IV infusion: $Css = \frac{Rate\ of\ infusion}{Clearance}$