Pharmacokinetics and Pharmacodynamics — Flashcards

Flashcard 131: The _____ of plasma concentration vs. time curve gives the extent of absorption.

Answer: AUC

Flashcard 132: The nomogram used for vancomycin dosing is the _____ nomogram.

Answer: Matzke

Flashcard 133: When the rate of drug **administration** equals the rate of drug **elimination**, the drug has reached _____ concentration.

Answer: Steady-state concentration (Css)

Extra: Steady-state is achieved when the rate of drug administration (input) equals the rate of drug elimination (output). It typically takes 4–5 half-lives (t½) to reach steady-state. Formula for IV infusion: $Css = \frac{Rate\ of\ infusion}{Clearance}$

Flashcard 134: The plasma half-life of beta hCG is _____ hours.

Answer: 36

Flashcard 135: The active metabolite of cyclophosphamide is _____ cyclophosphamide.

Answer: 4-hydroxy

Flashcard 136: Half life of methylprednisolone is _____ that of prednisolone.

Answer: equal

Flashcard 137: If a drug has _____ renal clearance than GFR, then drug is secreted in renal tubules.

Answer: more::more/less