Pharmacokinetics and Pharmacodynamics — Flashcards

Flashcard 1: What formula is used to calculate **loading dose**?

Answer: Loading Dose = $\frac{C_p \times V_d}{F}$

Extra: $C_p$ = target plasma concentration $V_d$ = volume of distribution $F$ = bioavailability

Flashcard 2: What is the formula for half-life (t1/2) in first-order elimination kinetics?

Answer: t1/2 = (0.693 × Vd) / CL

Extra: Where: - Vd = Volume of distribution - CL = Clearance Note: In first-order kinetics, the half-life is constant regardless of the plasma concentration.

Flashcard 3: What is the formula for Volume of Distribution (Vd)?

Answer: Vd = Amount of drug in the body / Plasma drug concentration (Cp)

Flashcard 4: What is the formula for calculating the **maintenance dose**? _____

Answer: (Cp × CL × τ) / F

Flashcard 5: Sketchy Pharmacology: Neuro/Psych Does the blue curve represent an inhaled anesthetic with a high or low blood solubility? _____

Answer: Low (quickly saturated, e.g. N2O)

Flashcard 6: _____ medications, blood products, and fluids can be administered through the Intraosseous route.

Answer: Any

Flashcard 7: Sketchy Pharmacology: Neuro/Psych Does the red curve represent an inhaled anesthetic with a high or low blood solubility? _____

Answer: High (slowly saturated, e.g. halothane)

Flashcard 8: in OPV _____ serotype has max efficiency and intestinal absorption

Answer: P2

Extra: 

Flashcard 9: Phenytoin follows _____-order kinetics at lower concentrations. As the concentration increases, the elimination changes to zero-order kinetics.

Answer: first

Flashcard 10: In first-order kinetics, a drug infused at a constant rate takes _____ - 5 half-lives to reach steady state

Answer: 4