Pharmacokinetics and Pharmacodynamics — Flashcards

Aminoglycosides exert _____-dependent killing and a long post-antibiotic effect

Hint: time/concentration

Warfarin's onset of action is _____ - 12 hours (slow)

_____ is a dipeptidyl-peptidase-4 (DPP-4) inhibitor eliminated by the hepatobiliary route.

Oral nitrate preparations require _____ dosing due to first pass metabolism

Cocaine is metabolised by _____ as well as the liver (primary)

Tertiary amine local anesthetics penetrate the cell membrane in a(n) _____ form and then bind to ion channels in a(n) charged form (charged or uncharged)

Pregabalin is a gabapentinoid that works by binding the _____ subunit of N-type voltage-gated calcium channels.

Typical antipsychotics have _____ lipid solubility and thus long half lives

Plasma levels of thiopental decrease rapidly due to redistribution to _____ and adipose

Thiopental is a barbiturate with a rapid onset and short duration of action due to its high _____ fraction and high lipid solubility.