Pharmacokinetics and Pharmacodynamics — Flashcards

Tertiary amine local anesthetics penetrate the cell membrane in a(n) _____ form and then bind to ion channels in a(n) charged form (charged or uncharged)

Antihistamines_____ generation H1 receptor antagonists may antagonize muscarinic receptors, leading to significant anti-cholinergic effects

_____ drugs generally bind to plasma albumin in the blood

Pegloticase converts _____ into water soluble allantoin

Aspirin at _____ doses decreases uric acid reabsorption in the renal tubules

At _____ urine pH, the B form of a weak base exists, thus decreasing excretion

About _____% of phenytoin is bound to plasma proteins -mainly albumin

All statins, except for _____, are metabolized by cytochrome p450

Drugs that are more _____ and have a higher volume of distribution are preferentially processed by the liver

Dialysis is _____ in removing drugs if they are sufficiently present in the free form in the plasma.