Pharmacokinetic Variability — Flashcards

10 flashcards

When the rate of drug **administration** equals the rate of drug **elimination**, the drug has reached _____ concentration.

The nomogram used for vancomycin dosing is the _____ nomogram.

Rocuronium, vecuronium, and rapacuronium are primarily dependent on the _____ for elimination.

Warfarin's onset of action is _____ - 12 hours (slow)

Which protease inhibitor undergoes metabolism by CYP2C19 instead of CYP3A4?_____

What formula is used to calculate **loading dose**?

What is the formula for half-life (t1/2) in first-order elimination kinetics?

What is the formula for Volume of Distribution (Vd)?

What is the formula for calculating the **maintenance dose**? _____

#10

Sketchy Pharmacology: Neuro/Psych Does the blue curve represent an inhaled anesthetic with a high or low blood solubility? _____

Pharmacokinetic Variability Indian Medical PG Flashcards - Medical Study Cards

Master Pharmacokinetic Variability with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.

Pharmacokinetic Variability Flashcard Deck - 10 Cards

Flashcard 1: When the rate of drug administration equals the rate of drug elimination, the drug has reached _____ concentration.

Answer: Steady-state concentration (Css)

Extra: Steady-state is achieved when the rate of drug administration (input) equals the rate of drug elimination (output). It typically takes 4–5 half-lives (t½) to reach steady-state. Formula for IV infusion: $Css = \frac{Rate\ of\ infusion}{Clearance}$

Flashcard 2: The nomogram used for vancomycin dosing is the _____ nomogram.

Answer: Matzke

Flashcard 3: Rocuronium, vecuronium, and rapacuronium are primarily dependent on the _____ for elimination.

Answer: Liver (biliary excretion)

Extra: Pancuronium is primarily eliminated by the kidneys (approx. 80%). Atracurium and cisatracurium undergo Hofmann elimination (spontaneous degradation in plasma independent of organ function). Rocuronium and vecuronium are the primary aminosteroid blockers that depend on hepatic clearance.

Flashcard 4: Warfarin's onset of action is _____ - 12 hours (slow)

Answer: 8

Flashcard 5: Which protease inhibitor undergoes metabolism by CYP2C19 instead of CYP3A4?_____

Answer: Nelfinavir

Flashcard 6: What formula is used to calculate loading dose?

Answer: Loading Dose = $\frac{C_p \times V_d}{F}$

Extra: $C_p$ = target plasma concentration $V_d$ = volume of distribution $F$ = bioavailability

Flashcard 7: What is the formula for half-life (t1/2) in first-order elimination kinetics?

Answer: t1/2 = (0.693 × Vd) / CL

Extra: Where: - Vd = Volume of distribution - CL = Clearance Note: In first-order kinetics, the half-life is constant regardless of the plasma concentration.

Flashcard 8: What is the formula for Volume of Distribution (Vd)?

Answer: Vd = Amount of drug in the body / Plasma drug concentration (Cp)

Flashcard 9: What is the formula for calculating the maintenance dose? _____

Answer: (Cp × CL × τ) / F

Flashcard 10: Sketchy Pharmacology: Neuro/Psych Does the blue curve represent an inhaled anesthetic with a high or low blood solubility? _____

Answer: Low (quickly saturated, e.g. N2O)

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Pharmacokinetic Variability Flashcards for NEET-PG

Study 10 flashcards on Pharmacokinetic Variability for NEET-PG Pharmacology. These active recall cards cover the key concepts, clinical associations, and high-yield facts from this chapter of Pharmacokinetics and Pharmacodynamics. Each card is designed to test your understanding rather than just recognition, building stronger and more durable memories for exam day.

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There are 10 flashcards for Pharmacokinetic Variability, covering the key concepts, clinical correlations, and high-yield facts from this chapter of Pharmacokinetics and Pharmacodynamics.

How should I use these flashcards for NEET-PG?

Read through each prompt and try to answer before revealing the back of the card. This active recall approach builds stronger memories than passive reading. Combine flashcards with the study notes and MCQ practice for the best results.

Are there more flashcards for Pharmacokinetics and Pharmacodynamics?

Yes. This page covers one chapter of Pharmacokinetics and Pharmacodynamics. Visit the topic page to see all chapters and their flashcards under Pharmacology.

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