Population Pharmacokinetics — Flashcards

Flashcard 1: The nomogram used for vancomycin dosing is the _____ nomogram.

Answer: Matzke

Flashcard 2: In first-order kinetics, a drug infused at a constant rate takes _____ - 5 half-lives to reach steady state

Answer: 4

Flashcard 3: Phenytoin follows _____-order kinetics at lower concentrations. As the concentration increases, the elimination changes to zero-order kinetics.

Answer: first

Flashcard 4: If a drug has _____ renal clearance than GFR, then drug is secreted in renal tubules.

Answer: more::more/less

Flashcard 5: Time for peak plasma concentration (Tmax) of a drug indicates the rate of _____ from the administered site.

Answer: absorption

Flashcard 6: _____ is when bioavailability of active ingredient in 2 preparations of drug are not significantly different under identical conditions

Answer: Bioequivalence

Flashcard 7: What formula is used to calculate **loading dose**?

Answer: Loading Dose = $\frac{C_p \times V_d}{F}$

Extra: $C_p$ = target plasma concentration $V_d$ = volume of distribution $F$ = bioavailability

Flashcard 8: What is the formula for half-life (t1/2) in first-order elimination kinetics?

Answer: t1/2 = (0.693 × Vd) / CL

Extra: Where: - Vd = Volume of distribution - CL = Clearance Note: In first-order kinetics, the half-life is constant regardless of the plasma concentration.

Flashcard 9: What is the formula for Volume of Distribution (Vd)?

Answer: Vd = Amount of drug in the body / Plasma drug concentration (Cp)

Flashcard 10: What is the formula for calculating the **maintenance dose**? _____

Answer: (Cp × CL × τ) / F