Anticancer Drugs — Flashcards

_____ acts as a competitive antagonist of the SMO (Smoothened) receptor in the Hedgehog signaling pathway.

_____ is an antimetabolite that inhibits DNA synthesis by inhibiting Ribonucleotide Reductase, thus blocking Thymidine synthesis.

Vinblastine and Vincristine treat both _____ and solid tumor malignancies

_____ is a bispecific monoclonal antibody, that binds simultaneously to CD3 on T cells and to CD19 on B cells.

Alkylating agents donate an _____ group that cross-links DNA, resulting in cell apoptosis

Secondary mechanism of action of _____ is inhibition of AICAR transformylase

Bevacizumab has an increased risk of _____ and thrombotic events

Prostatic adenocarcinoma may be treated with _____ analogs (e.g. leuprolide) and/or androgen receptor inhibitors (e.g. flutamide)

Ifosfamide use can result in _____, with the bladder toxicity arising from the metabolite acrolein

Interferon _____ may be used in the treatment of neoplasms, including hairy cell leukemia and malignant melanoma