Anticancer Drugs — Flashcards

Flashcard 81: _____ is a prodrug of 5-fluorouracil with similar activity

Answer: Capecitabine

Flashcard 82: The P-glycoprotein is an _____-dependent efflux pump that tumors can produce to generate chemotherapeutic resistance

Answer: ATP

Flashcard 83: _____ is an androgen receptor inhibitor indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer.

Answer: Apalutamide

Flashcard 84: Bifunctional alkylating agents usually transfer _____ groups to DNA, resulting in cross-linking.

Answer: alkyl

Extra: Alkylating agents most commonly attach an alkyl group to the N7 position of guanine. Bifunctional agents (e.g., nitrogen mustards, nitrosoureas, busulfan) have two reactive groups, allowing them to form DNA cross-links (interstrand or intrastrand).

Flashcard 85: _____ is an antimetabolite that inhibits DNA synthesis by inhibiting Ribonucleotide Reductase, thus blocking Thymidine synthesis.

Answer: Hydroxyurea

Flashcard 86: Bevacizumab has an increased risk of _____ and thrombotic events

Answer: bleeding

Flashcard 87: Interferon _____ may be used in the treatment of neoplasms, including hairy cell leukemia and malignant melanoma

Answer: alpha

Flashcard 88: Prostatic adenocarcinoma may be treated with _____ analogs (e.g. leuprolide) and/or androgen receptor inhibitors (e.g. flutamide)

Answer: GnRH

Flashcard 89: _____ is a small-molecule inhibitor of BCL-2

Answer: Venetoclax

Flashcard 90: Secondary mechanism of action of _____ is inhibition of AICAR transformylase

Answer: Methotrexate