Anticancer Drugs — Flashcards

Vinblastine and Vincristine treat both _____ and solid tumor malignancies

_____ is a monoclonal antibody against glycolipid GD2 approved for pediatric neuroblastoma

_____ works as an EGFR tyrosine kinase inhibitor

Platinum based antineoplastics can cause side effects which might make ya say NOPE- _____, in particular Acute Tubular Necrosis- Ototoxicity- Peripheral Neuropathy- Emesis

Platinum analogs (-platin suffix) bind _____ and form intra-strand and inter-strand cross-links

Alkylating agents donate an _____ group that cross-links DNA, resulting in cell apoptosis

_____ is a bispecific monoclonal antibody, that binds simultaneously to CD3 on T cells and to CD19 on B cells.

_____ acts as a competitive antagonist of the SMO (Smoothened) receptor in the Hedgehog signaling pathway.

Anthracyclines (doxorubicin, daunorubicin) form _____ which cause breaks in DNA

Trastuzumab works by binding _____, preventing it from dimerizing with the EGFR receptor