Anticancer Drugs — Flashcards

Flashcard 71: _____ is a monoclonal antibody against glycolipid GD2 approved for pediatric neuroblastoma

Answer: Dinutuximab

Flashcard 72: Platinum analogs (-platin suffix) bind _____ and form intra-strand and inter-strand cross-links

Answer: DNA

Flashcard 73: The P-glycoprotein is an _____-dependent efflux pump that tumors can produce to generate chemotherapeutic resistance

Answer: ATP

Flashcard 74: _____ is an androgen receptor inhibitor indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer.

Answer: Apalutamide

Flashcard 75: Platinum based antineoplastics can cause side effects which might make ya say NOPE- _____, in particular Acute Tubular Necrosis- Ototoxicity- Peripheral Neuropathy- Emesis

Answer: Nephrotoxicity

Flashcard 76: _____ works as an EGFR tyrosine kinase inhibitor

Answer: Erlotinib

Flashcard 77: Bifunctional alkylating agents usually transfer _____ groups to DNA, resulting in cross-linking.

Answer: alkyl

Extra: Alkylating agents most commonly attach an alkyl group to the N7 position of guanine. Bifunctional agents (e.g., nitrogen mustards, nitrosoureas, busulfan) have two reactive groups, allowing them to form DNA cross-links (interstrand or intrastrand).

Flashcard 78: _____ is a prodrug of 5-fluorouracil with similar activity

Answer: Capecitabine

Flashcard 79: Trastuzumab works by binding _____, preventing it from dimerizing with the EGFR receptor

Answer: HER2/neu

Flashcard 80: Anthracyclines (doxorubicin, daunorubicin) form _____ which cause breaks in DNA

Answer: free radicals