Management of Chemotherapy Side Effects — Flashcards

Flashcard 1: Procarbazine side effects include _____ and secondary leukemia. *Bonus: Patients should avoid what type of food?*

Answer: pulmonary toxicity

Extra: Procarbazine is a methylating agent (alkylating agent class) used in the MOPP regimen for Hodgkin lymphoma. Key Side Effects/Interactions: 1. **MAO Inhibition**: Requires a low-tyramine diet to avoid hypertensive crisis. 2. **Disulfiram-like reaction**: Avoid alcohol. 3. **Bone Marrow Suppression**: Anemia, leukopenia, thrombocytopenia. 4. **Leukemogenicity**: High risk of secondary leukemias. 5. **Pulmonary Toxicity**: Rare but reported (interstitial pneumonitis).

Flashcard 2: Thymidine synthesis inhibitor (MTX, 5-FU, hydroxyurea) use can result in _____-suppression and pan-cytopenia

Answer: myelo

Flashcard 3: Ifosfamide use can result in _____, with the bladder toxicity arising from the metabolite acrolein

Answer: hemorrhagic cystitis

Flashcard 4: When injected intravenously, 5FU can be used to treat _____ cancer and pancreatic cancer

Answer: colon

Flashcard 5: Cerebellar toxicity is seen with which anti-cancer drug?_____

Answer: Cytarabine

Flashcard 6: Radiation recall syndrome is associated with the use of which anti-cancer drugs?_____

Answer: Anthracyclines

Flashcard 7: Antineoplastic agents extracted from the Periwinkle plant is: _____ also called Catharanthus roseus

Answer: Vinca alkaloids

Flashcard 8: Aldesleukin is a recombinant form of _____ used to treat renal cell carcinoma and metastatic melanoma

Answer: IL-2

Flashcard 9: Cetuximab is a monoclonal antibody against the _____ Receptor most commonly used to treat Stage IV colorectal cancer

Answer: EGF

Flashcard 10: _____ is a drug of choice for mesothelioma.

Answer: Pemetrexed