Principles of Cancer Chemotherapy — Flashcards

Flashcard 1: Present chemotherapy regimen used for breast cancer is ACT, i.e., _____, Cyclophosphamide, and Taxane (Paclitaxel)

Answer: Adriamycin

Flashcard 2: Proteasomal inhibitors (_____) are antineoplastics that inhibit cell cycle progression at the G2-M phase

Answer: -zomibs

Flashcard 3: Anthracyclines (doxorubicin, daunorubicin) _____ into DNA, blocking DNA and RNA synthesis

Answer: intercalate

Flashcard 4: Platinum based antineoplastics can cause side effects which might make ya say NOPE- _____, in particular Acute Tubular Necrosis- Ototoxicity- Peripheral Neuropathy- Emesis

Answer: Nephrotoxicity

Flashcard 5: -Posides (Topoisomerase II inhibitor antineoplastics) are used to treat solid tumors, particularly _____ cancer and small cell lung cancer

Answer: testicular

Flashcard 6: Methotrexate resistance is due to the overproduction of _____

Answer: DHFR.

Flashcard 7: The effects of 5-fluorouracil can be _____ with leucovorin

Answer: potentiated

Flashcard 8: What cell cycle phase is 5-FU (5-Fluorouracil) specific for?

Answer: S phase

Extra: 5-FU is a pyrimidine analog (antimetabolite) that inhibits thymidylate synthase, thereby inhibiting DNA synthesis. Like most antimetabolites, it is **S-phase specific**. Note: While some studies show concentration-dependent effects on other phases (like G2), for medical examinations (NEET PG, USMLE), 5-FU is the classic example of an S-phase specific drug.

Flashcard 9: Cerebellar toxicity is seen with which anti-cancer drug?_____

Answer: Cytarabine

Flashcard 10: Antineoplastic agents extracted from the Periwinkle plant is: _____ also called Catharanthus roseus

Answer: Vinca alkaloids