Anticancer Drugs — Flashcards

Ifosfamide use can result in _____, with the bladder toxicity arising from the metabolite acrolein

_____ intercalate into DNA, inhibiting Topoisomerase II and inducing eviction of histones.

_____ is a Hedgehog pathway inhibitor, used for eye-sparing adjuvant therapy of periocular and orbital BCC

Etoposide and teniposide can result in _____-suppression and immuno-suppression

Which two solid tumors specifically can etoposide and teniposide (topoisomerase II inhibitors) be used to treat?_____, Small cell lung carcinoma

The main acute side effect of Tisagenlecleucel is _____ while a potential long term risk is the potential for insertional mutagenesis

Because sorafenib targets VEGF, areas that are highly vascularized will be affected such as the _____ and the kidney

Which chemotherapeutic drugs are associated with hemorrhagic cystitis with acrolein in urine?_____

_____ and olaparib are PARP inhibitors approved for the treatment of advanced ovarian cancer.

Bleomycin forms _____ which cause breaks in DNA