Anticancer Drugs — Flashcards

Platinum based antineoplastics can cause side effects which might make ya say NOPE- _____, in particular Acute Tubular Necrosis- Ototoxicity- Peripheral Neuropathy- Emesis

Platinum analogs (-platin suffix) bind _____ and form intra-strand and inter-strand cross-links

_____ works as an EGFR tyrosine kinase inhibitor

_____ is a bispecific monoclonal antibody, that binds simultaneously to CD3 on T cells and to CD19 on B cells.

Alkylating agents donate an _____ group that cross-links DNA, resulting in cell apoptosis

Prostatic adenocarcinoma may be treated with _____ analogs (e.g. leuprolide) and/or androgen receptor inhibitors (e.g. flutamide)

_____ is a small-molecule inhibitor of BCL-2

Interferon _____ may be used in the treatment of neoplasms, including hairy cell leukemia and malignant melanoma

Secondary mechanism of action of _____ is inhibition of AICAR tranformylase

Ifosfamide use can result in _____, with the bladder toxicity arising from the metabolite acrolein