Anticancer Drugs — Flashcards

Which of the cytotoxic microtubule inhibitors prevent mitotic spindle formation?_____

Ifosfamide can cause neurotoxicity due to buildup of its metabolite _____, which can be treated with methylene blue

_____ inhibits thymidylate synthase, which catalyzes conversion of dUMP to dTMP (pyrimidine synthesis)

Taxanes are used to treat for _____ and ovarian carcinomas

Because Bevacizumab impairs sustained _____, this makes it especially useful for metastatic tumors

Antineoplastic agents extracted from the _____ plant (Catharanthus roseus) are the Vinca alkaloids.

Actinomycin D _____ into DNA, blocking DNA and RNA synthesis

_____ is an immunostimulant that works by targeting the PD-1 receptor

_____ and allopurinol are used prior to initiation of chemotherapy to decrease risk of urate-induced acute tubular necrosis

_____ is a cytotoxic plant alkaloid associated with peripheral neuropathy (neurotoxicity)