Anticancer Drugs — Flashcards

Cyclophosphamide can be used as an immunosuppresant for the treatment of _____ nephritis, as well as for systemic vasculitides

As two classes of antineoplastic agents that modulate microtubule structure, the distinction lies in that vinca-alkaloids prevent microtubule _____ whereas taxanes prevent microtubule disassembly

As an antineoplastic, Denosumab can be used for _____ as well as metastases to bone

Cyclosporine and Tacrolimus are _____ inhibitors that block T cell activation by preventing IL-2 transcription

_____ inhibits the enzyme dihydrofolate reductase in eukaryotes (pyrimidine synthesis)

As an antineoplastic, Methotrexate is primarily indicated for cancers of lymphocytes, particularly _____ and lymphomas

Metastatic or unresectable melanoma in patients with BRAF _____ mutations may benefit from vemurafenib, a BRAF kinase inhibitor

Hint: AAs

_____ directly inhibits PRPP amidotransferase, which normally catalyzes conversion of PRPP to 5-phosphoribosylamine (purine synthesis)

Both _____ and cetuximab are antitumor chimeric antibodies associated with serum sickness

Which of the cytotoxic microtubule inhibitors bind β-tubulin and inhibit polymerization? _____