Anticancer Drugs — Flashcards

As an antineoplastic, Denosumab can be used for _____ as well as metastases to bone

Trastuzumab is indicated for _____-positive cancers, the most important example being breast cancer

Eribulin is a chemotherapeutic that works by inhibiting microtubule _____ and sequestering tubulin into nonfunctional aggregates

As two classes of antineoplastic agents that modulate microtubule structure, the distinction lies in that vinca-alkaloids prevent microtubule _____ whereas taxanes prevent microtubule disassembly

Metastatic or unresectable melanoma in patients with BRAF _____ mutations may benefit from vemurafenib, a BRAF kinase inhibitor

Hint: AAs

_____ inhibits the enzyme dihydrofolate reductase in eukaryotes (pyrimidine synthesis)

As an antineoplastic, Methotrexate is primarily indicated for cancers of lymphocytes, particularly _____ and lymphomas

Which of the cytotoxic microtubule inhibitors bind β-tubulin and inhibit polymerization? _____

Both _____ and cetuximab are antitumor chimeric antibodies associated with serum sickness

_____ directly inhibits PRPP amidotransferase, which normally catalyzes conversion of PRPP to 5-phosphoribosylamine (purine synthesis)