Anticancer Drugs — Flashcards

Flashcard 11: Palbociclib is used to treat Breast Cancer that is ER _____ and HER2 -

Answer: +

Flashcard 12: Cyclophosphamide can be used as an immunosuppresant for the treatment of _____ nephritis, as well as for systemic vasculitides

Answer: lupus

Flashcard 13: Cyclosporine and Tacrolimus are _____ inhibitors that block T cell activation by preventing IL-2 transcription

Answer: calcineurin

Flashcard 14: Trastuzumab is indicated for _____-positive cancers, the most important example being breast cancer

Answer: Her2

Flashcard 15: Platinum based antineoplastics are indicated for various carcinomas that affect the _____ system, Reproductive system, and Respiratory system

Answer: Genitourinary

Flashcard 16: _____ is a MEK inhibitor that is often co-administered with dabrafenib.

Answer: Trametinib

Extra: Trametinib (MEK inhibitor) is typically paired with Dabrafenib (BRAF inhibitor) for the treatment of BRAF V600E/K-mutant melanoma. Using both classes together helps delay the emergence of resistance and reduces certain side effects (like squamous cell carcinomas) caused by BRAF inhibitors alone.

Flashcard 17: As an antineoplastic, Denosumab can be used for _____ as well as metastases to bone

Answer: Giant Cell Tumor of Bone

Flashcard 18: Eribulin is a chemotherapeutic that works by inhibiting microtubule _____ and sequestering tubulin into nonfunctional aggregates

Answer: assembly

Flashcard 19: Basiliximab is used prophylactically to reduce _____ in patients who have received kidneys

Answer: transplant rejection

Flashcard 20: Because Her2/Neu is expressed on the _____, Trastuzumab can cause Heart failure

Answer: Heart