Systemic Pathology — Flashcards

Flashcard 881: Reticulocyte count may be falsely _____ in anemia

Answer: elevated

Flashcard 882: Nephritic syndrome occurs due to _____ disruption

Answer: GBM

Flashcard 883: Vaginal carcinoma arises from the _____ epithelium lining the vaginal mucosa

Answer: stratified squamous

Flashcard 884: Osmotic demyelination syndrome is characterized by massive axonal demyelination of the _____ (brain stem area)

Answer: pons

Flashcard 885: Frontotemporal dementia may have ubiquitinated _____ inclusions seen on histology

Answer: TDP-43

Extra: Frontotemporal Lobar Degeneration (FTLD) is divided into subtypes based on the protein inclusions: 1. **FTLD-TDP** (most common): TDP-43 inclusions; often associated with ALS (e.g., C9orf72 mutations). 2. **FTLD-Tau**: Tau inclusions; includes **Pick disease**, which is characterized by spherical Tau-positive Pick bodies. Note: While Pick bodies are ubiquitinated, TDP-43 is the protein specifically associated with the "ubiquitinated-only" (non-tau) inclusions in FTD.

Flashcard 886: Ammonium magnesium phosphate (struvite) kidney stones classically form _____ in renal calyces

Answer: staghorn calculi

Flashcard 887: Chronic pyelonephritis with scarring at the upper and lower poles is characteristic of _____

Answer: vesicoureteral reflux

Flashcard 888: Circulating _____ deposition causes glomerular damage and subsequent nephritic syndrome in Post-strep glomerulonephritis

Answer: immune complex

Flashcard 889: The E. coli O157:H7 _____-toxin damages endothelial cells, resulting in platelet microthrombi (e.g. HUS)

Answer: vero

Flashcard 890: What MSK pathology presents with bone pain and systemic signs of infection (e.g. fever, leukocytosis)?_____

Answer: Osteomyelitis