Systemic Pathology — Flashcards

Flashcard 881: Frontotemporal dementia may have ubiquitinated _____ inclusions seen on histology

Answer: TDP-43

Extra: Frontotemporal Lobar Degeneration (FTLD) is divided into subtypes based on the protein inclusions: 1. **FTLD-TDP** (most common): TDP-43 inclusions; often associated with ALS (e.g., C9orf72 mutations). 2. **FTLD-Tau**: Tau inclusions; includes **Pick disease**, which is characterized by spherical Tau-positive Pick bodies. Note: While Pick bodies are ubiquitinated, TDP-43 is the protein specifically associated with the "ubiquitinated-only" (non-tau) inclusions in FTD.

Flashcard 882: Nephritic syndrome occurs due to _____ disruption

Answer: GBM

Flashcard 883: Chronic pyelonephritis with scarring at the upper and lower poles is characteristic of _____

Answer: vesicoureteral reflux

Flashcard 884: The 'tram-track' appearance associated with MPGN is due to basement membrane splitting caused by _____ cell ingrowth

Answer: mesangial

Flashcard 885: What chromosomal deletion is associated with DiGeorge syndrome? _____

Answer: 22q11 microdeletion

Flashcard 886: The third most common type of kidney stone (5%) is a _____ stone

Answer: uric acid

Flashcard 887: What eye pathology is associated with galactokinase deficiency? _____

Answer: Cataracts

Flashcard 888: Ammonium magnesium phosphate (struvite) kidney stones classically form _____ in renal calyces

Answer: staghorn calculi

Flashcard 889: Reticulocyte count may be falsely _____ in anemia

Answer: elevated

Flashcard 890: Vaginal carcinoma arises from the _____ epithelium lining the vaginal mucosa

Answer: stratified squamous