Systemic Pathology — Flashcards

Flashcard 411: Multiple sclerosis is characterized by increased levels of Ig_____ in the CSF

Answer: G

Extra: Atlas:

Flashcard 412: In diabetes patients, blindness occurs as a result of osmotic damage to _____ of retinal blood vessels, weakening the vessel wall and causing aneurysm formation

Answer: pericytes

Extra: * (arrows pointing to pericytes in DM patient vs. control)

Flashcard 413: Primary amyloidosis is characterized by systemic deposition of _____, which is derived from Ig light chain

Answer: AL amyloid

Extra: * AL = amyloid light chain;

Flashcard 414: Which blistering skin disorder presents with tense blisters with eosinophils that don't rupture easily? _____

Answer: Bullous pemphigoid

Extra: Atlas:

Flashcard 415: Intrarenal azotemia is less commonly due to acute _____ or acute interstitial nephritis

Answer: glomerulonephritis

Flashcard 416: Appropriate absolute polycythemia is characterized by _____ O2 saturation

Answer: decreased

Extra: Causes of appropriate absolute polycythemia (hypoxia-driven): - High altitude - COPD / Chronic lung disease - Right-to-left cardiac shunts - Obesity hypoventilation syndrome (Pickwickian syndrome)

Flashcard 417: The most common type of metastases to the bone from the breast are _____

Answer: mixed

Flashcard 418: Precipitation of Hemoglobin Bart’s (alpha thalassemia major) into inclusion bodies may result in _____

Answer: extravascular hemolysis

Extra: * Should say Hemoglobin Bart's NOT Hemoglobin H in sketchy

Flashcard 419: Tuberous Sclerosis may present with _____ hamartomas most common in the cerebral cortex

Answer: glioneuronal "cortical tubers"

Flashcard 420: Calcium oxalate kidney stones are characterized by urine crystals in the shape of a(n) _____ or dumbbell

Answer: envelope

Extra: * "elongated wedge" shape, FA describes it as envelope