Lipid metabolism — Flashcards

Flashcard 221: _____ CoA is the only fatty acid carbon that may be used to make glucose (via gluconeogenesis)

Answer: Propionyl

Extra:    https://onlinemeded.org/spa/metabolism/gluconeogenesis/acquire?ref=anki 

Flashcard 222: Fat-soluble deficiencies may occur with syndromes that cause _____ (e.g. cystic fibrosis and sprue)

Answer: steatorrhea

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/physiology?index=16] https://onlinemeded.org/spa/gastroenterology/malabsorption/acquire?ref=anki 

Flashcard 223: Cholesterol ester inside of mature HDL may be transferred to VLDL, IDL, or LDL via the enzyme _____

Answer: cholesterol ester transport protein (CETP)

Extra:   https://onlinemeded.org/spa/metabolism?ref=anki 

Flashcard 224: Type _____ hyperlipoproteinemia is also known as familial hyperchylomicronemia syndrome

Answer: I

Extra:   https://onlinemeded.org/spa/metabolism?ref=anki 

Flashcard 225: What protein is responsible for the rate limiting step in steroidogenesis? _____

Answer: StAR (Steroidogenic acute regulatory protein)

Flashcard 226: The enzyme _____ is deficient in Tay-Sachs disease

Answer: hexosaminidase A

Extra:    https://onlinemeded.org/spa/metabolism?ref=anki 

Flashcard 227: What is the mode of inheritance of type IIa familial dyslipidemia? _____

Answer: Autosomal dominant

Extra:   https://onlinemeded.org/spa/metabolism?ref=anki 

Flashcard 228: In the liver, bile acids are conjugated to the amino acids _____ or taurine to form bile salts

Answer: glycine

Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/gastroenterology/videos/physiology?index=8] https://onlinemeded.org?ref=anki 

Flashcard 229: In **β-oxidation**, fatty acyl-CoA is broken down into molecules of _____; the rate-limiting step is catalyzed by acyl-CoA dehydrogenase.

Answer: acetyl CoA

Extra: β-oxidation occurs in the mitochondrial matrix. The acetyl-CoA produced can enter the TCA cycle or be used for ketogenesis (in the liver).

Flashcard 230: Which androgen is the most potent? _____

Answer: DHT > testosterone > androstenedione

Extra:  Watch Benign Prostatic Hyperplasia (BPH) & Prostate Cancer [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-male-gu-benign-prostatic-hyperplasia-bph-and-prostate-cancer?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/endocrinology?ref=anki