Lipid metabolism — Flashcards

Flashcard 231: Which androgen is the most potent? _____

Answer: DHT > testosterone > androstenedione

Flashcard 232: What substrate accumulates in the lysosomes of a patient with Niemann Pick disease? _____

Answer: Sphingomyelin

Flashcard 233: What enzyme activates vitamin K? _____

Answer: Epoxide reductase

Flashcard 234: What is the mode of inheritance of type I hyperlipoproteinemia? _____

Answer: Autosomal recessive

Flashcard 235: Dehydroepiandrosterone (DHEA) may be converted to _____ via the enzyme 3β-hydroxysteroid dehydrogenase

Answer: androstenedione

Flashcard 236: One external source of vitamin D (cholecalciferol) in the body is through _____

Answer: ingestion/diet

Extra: * other external source is UV light

Flashcard 237: What is the rate-limiting enzyme of fatty acid β-oxidation? _____

Answer: Carnitine palmitoyl transferase-1 (CPT-1)

Flashcard 238: Medium chain acyl-CoA dehydrogenase (MCAD) deficiency may present in infancy or early childhood with _____, hyperammonemia, lethargy, seizures, coma, and liver dysfunction

Answer: vomiting

Flashcard 239: The acetyl CoA generated through β-oxidation is used for _____ (liver) or the TCA cycle

Answer: ketogenesis

Flashcard 240: Which enzyme of the fatty acid synthesis pathway utilizes NADPH? _____

Answer: Fatty acid synthase