Pharmacokinetics and Pharmacodynamics — Flashcards

The pharmacological actions of heroin are mainly attributed to metabolites _____ and morphine.

Quinine has a _____ effect on pancreatic beta cells and can cause hypoglycemia.

Hint: inhibitory/stimulatory

PDE-5 inhibitors work by preventing breakdown of _____ to produce prolonged smooth muscle relaxation

Platelet-activating factor is given through the intra_____ route maintaining an angle of 15 degrees

Aspirin at _____ doses inhibits uric acid excretion in the renal tubules

Mechanism of action of MgSO4: It is a membrane _____ and a neuroprotector by reducing motor endplate sensitivity to Ach

Because propofol is highly _____, it quickly accumulates in tissues receiving high blood flow, and then is slowly redistributed to organs receiving less blood flow

At _____ urine pH, the A- form of a weak acid exists, thus increasing excretion

Probenecid _____ proximal renal tubular reabsorption of uric acid

All of the _____ local anesthetics are metabolised by amidases in the liver except articaine

Hint: class