Pharmacokinetics and Pharmacodynamics — Flashcards

Since methotrexate is a _____, a methotrexate overdose can be treated with Bicarbonate in order to alkalinize urine

By interfering with tubulin function, Colchicine disrupts the _____ of neutrophils

Hint: cellular element

Probenecid _____ proximal renal tubular reabsorption of uric acid

In _____ order kinetics clearance is more at low concentration and less at high concentration

In _____ order kinetics, half-life is less at low concentration and more at high concentration

Fenoldopam exerts its effects by acting on the D_____ receptor (A Gs receptor), thus increasing levels of cAMP, causing vasodilation in most arterial beds

After a single use of marijuana, _____ (active principle of Cannabis) can be detected in urine tests for up to 3 days.

P-glycoprotein is normally found in the _____ and renal tubular epithelial cells to eliminate foreign compounds from the body

_____ drugs generally bind to alpha-1 acid glycoprotein in the blood

Nonbenzodiazepine hypnotics have a _____ duration of action due to rapid metabolism by the liver