Anticancer Drugs — Flashcards

_____ is a prodrug of 5-fluorouracil with similar activity

The P-glycoprotein is an _____-dependent efflux pump that tumors can produce to generate chemotherapeutic resistance

_____ is an androgen receptor inhibitor indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer.

_____ is a monoclonal antibody against glycolipid GD2 approved for pediatric neuroblastoma

Vinblastine and Vincristine treat both _____ and solid tumor malignancies

_____ acts as a competitive antagonist of the SMO (smoothens hedgehog) receptor in the hedgehog signaling pathway.

Anthracyclines (doxorubicin, daunorubicin) form _____ which cause breaks in DNA

Traztusumab works by binding _____, preventing it from dimerizing with the EGFR receptor

Bifunctional alkylating agents usually transfers _____ group to DNA resulting in cross-linking.

_____ is an antimetabolite that inhibits pyrimidine synthesis inhibiting Ribonucleotide Reductase, thus blocking Thymidine synthesis