Anticancer Drugs — Flashcards

Cyclophosphamide can be used as an immunosuppresant for the treatment of _____ nephritis, as well as for systemic vasculitides

Eribulin is a chemotherapeutic that works by inhibiting microtubule _____ and sequestering tubulin into nonfunctional aggregates

Platinum based antineoplastics are indicated for various carcinomas that affect the _____ system, Reproductive system, and Respiratory system

_____ and sorafenib are small molecules that inhibit the VEGFR tyrosine kinase

Both _____ and cetuximab are antitumor chimeric antibodies associated with serum sickness

_____ inhibits the enzyme dihydrofolate reductase in eukaryotes (pyrimidine synthesis)

Which of the cytotoxic microtubule inhibitors bind -tubulin and inhibit polymerization?_____

_____ directly inhibits PRPP amidotransferase, which normally catalyzes conversion of PRPP to 5-phosphoribosylamine (purine synthesis)

Metastatic or unresectable melanoma in patients with BRAF _____ mutations may benefit from vemurafenib, a BRAF kinase inhibitor

Hint: AAs

As an antineoplastic, Methotrexate is primarily indicated for cancers of lymphocytes, particularly _____ and lymphomas