Neoplasia — Flashcards

Flashcard 41: Tumors that cause _____ can be remembered with the mnemonic "Potentially Really High Hematocrit Levels": - Pheochromocytoma - Renal cell carcinoma - Hepatocellular carcinoma - Hemangioblastoma - Leiomyoma

Answer: paraneoplastic polycythemia

Flashcard 42: Hereditary leiomyomatosis and RCC is due to _____ gene mutation and presents with multiple, bilateral type 2 papillary RCC, collecting duct RCC, leiomyomas of the skin or uterus and uterine leiomyosarcomas

Answer: fumarate hydratase

Flashcard 43: _____ is a subtype of DCIS (breast) characterized by ducts filled with high-grade cells and central necrosis which often shows dystrophic calcification.

Answer: Comedocarcinoma

Extra: The term "comedo" refers to the necrotic debris which can be squeezed from the ducts like toothpaste or a comedone (blackhead) during gross examination.

Flashcard 44: MEN 1 is associated with mutation of the _____ gene (menin), which is a tumor suppressor gene found on chromosome 11

Answer: MEN1

Flashcard 45: _____ is the assessment of the size and spread of a cancer

Answer: Staging

Flashcard 46: Li-Fraumeni Syndrome is also known as "SBLA" Syndrome, which stands for:S - _____B - Breast CancerL - LeukemiaA - Adrenal Gland tumor

Answer: Sarcoma

Flashcard 47: Almost all _____ are calretinin positive, which is negative in most carcinomas

Answer: mesotheliomas

Flashcard 48: Ovarian carcinoma is associated with '_____', which occurs from seeding of the peritoneum with layers upon layers of tumor cell growth

Answer: omental caking

Flashcard 49: Invasive carcinomas become metastatic when they invade the _____ or blood

Answer: lymphatics

Flashcard 50: A translocation of _____ from chromosome 11 to 14 results in overexpression and ultimately Mantle cell lymphoma

Answer: cyclin D1