Neoplasia — Flashcards

Flashcard 31: _____ carcinoma of the lung may produce PTHrP leading to hyper-calcemia

Answer: Squamous cell

Flashcard 32: _____ is a subtype of DCIS (breast) characterized by ducts filled with high-grade cells and central necrosis which often shows dystrophic calcification.

Answer: Comedocarcinoma

Extra: The term "comedo" refers to the necrotic debris which can be squeezed from the ducts like toothpaste or a comedone (blackhead) during gross examination.

Flashcard 33: Histopathology of mesothelioma will show tumor cells with numerous, long slender _____ and abundant tonofilaments

Answer: microvilli

Flashcard 34: MEN 1 is associated with mutation of the _____ gene (menin), which is a tumor suppressor gene found on chromosome 11

Answer: MEN1

Flashcard 35: HPV encodes E6 and E7 which promotes proteolysis of _____ and Rb.

Answer: p53

Flashcard 36: Smooth muscle can give rise to a _____ (benign) and leiomyosarcoma (malignant)

Answer: leiomyoma

Flashcard 37: The t(_____,14) translocation results in overexpression of Cyclin D1, which promotes the G1/S transition in the cell cycle, facilitating neoplastic proliferation

Answer: 11

Flashcard 38: Esophageal carcinoma in the middle third of the esophagus spreads to _____, tracheobronchial, or paratracheal lymph nodes

Answer: mediastinal

Flashcard 39: _____ cystadenocarcinoma may present with pseudomyxoma peritonei, which is an intraperitoneal accumulation of mucinous material, usually from a GI, ovarian, appendiceal tumor

Answer: Mucinous

Flashcard 40: Common sites of metastasis from lung cancer include the _____, brain, bone, and liver

Answer: adrenal gland