Neoplasia — Flashcards

Flashcard 31: _____ is a subtype of DCIS (breast) characterized by ducts filled with high-grade cells and central necrosis which often shows dystrophic calcification.

Answer: Comedocarcinoma

Extra: The term "comedo" refers to the necrotic debris which can be squeezed from the ducts like toothpaste or a comedone (blackhead) during gross examination.

Flashcard 32: HPV encodes E6 and E7 which promotes proteolysis of _____ and Rb.

Answer: p53

Flashcard 33: The t(_____,14) translocation results in overexpression of Cyclin D1, which promotes the G1/S transition in the cell cycle, facilitating neoplastic proliferation

Answer: 11

Flashcard 34: Common sites of metastasis from lung cancer include the _____, brain, bone, and liver

Answer: adrenal gland

Flashcard 35: _____ carcinoma of the lung may produce PTHrP leading to hyper-calcemia

Answer: Squamous cell

Flashcard 36: Smooth muscle can give rise to a _____ (benign) and leiomyosarcoma (malignant)

Answer: leiomyoma

Flashcard 37: Tumors that cause _____ can be remembered with the mnemonic "Potentially Really High Hematocrit Levels": - Pheochromocytoma - Renal cell carcinoma - Hepatocellular carcinoma - Hemangioblastoma - Leiomyoma

Answer: paraneoplastic polycythemia

Flashcard 38: Histopathology of mesothelioma will show tumor cells with numerous, long slender _____ and abundant tonofilaments

Answer: microvilli

Flashcard 39: Ovarian serous adenocarcinoma is CK 7 _____ and CK 20 negative

Answer: positive

Flashcard 40: Esophageal carcinoma in the middle third of the esophagus spreads to _____, tracheobronchial, or paratracheal lymph nodes

Answer: mediastinal