Neoplasia — Flashcards

MEN 1 is associated with mutation of the _____ gene (menin), which is a tumor suppressor gene found on chromosome 11

_____ carcinoma of the lung may produce PTHrP leading to hyper-calcemia

HPV encodes E6 and E7 which promotes proteolysis of _____ and Rb.

The t(_____,14) translocation results in overexpression of Cyclin D1, which promotes the G1/S transition in the cell cycle, facilitating neoplastic proliferation

Common sites of metastasis from lung cancer include the _____, brain, bone, and liver

Ovarian serous adenocarcinoma is CK 7 _____ and CK 20 negative

Which four carcinomas route hematogenously?_____ChoriocarcinomaRenal cell carcinomaHepatocellular carcinoma

Smooth muscle can give rise to a _____ (benign) and leiomyosarcoma (malignant)

_____ cystadenocarcinoma may present with pseudomyxoma peritonei, which is an intraperitoneal accumulation of mucinous material, usually from a GI, ovarian, appendiceal tumor

Tumors that cause _____ can be remembered with the mnemonic "Potentially Really High Hematocrit Levels": - Pheochromocytoma - Renal cell carcinoma - Hepatocellular carcinoma - Hemangioblastoma - Leiomyoma