Carcinogenesis and Carcinogens — Flashcards

_____ is the most commonly mutated gene in sporadic breast carcinomas

Neoplasia is new tissue growth which has three characteristics that distinguish it from hyperplasia and repair:1 - It is _____ 2 - It is irreversible3 - Generally speaking, it is monoclonal*

Activating mutation in _____ is responsible for bladder carcinoma.

To remember the most common neoplasias that spread _____Embryonal carcinomaHepatocellular carcinomaSarcomaChoriocarcinomaRenal cell carcinomaFollicular carcinoma of the thyroid

2-Naphthylamine is a carcinogenic aromatic amine found in _____ associated with Transitional Cell Carcinoma of the Bladder

What is the chromosomal translocation that results in malignancy from the **ABL** oncogene? _____

The t(_____,14) translocation results in overexpression of Cyclin D1, which promotes the G1/S transition in the cell cycle, facilitating neoplastic proliferation

_____ is a protein from high-risk HPV that binds to p53.

In non-seminomatous germ-cell tumors (NSGCT), _____ enzyme is directly related to tumor burden

The following image represents the _____ carcinoma subtype of invasive ductal carcinoma (breast): hint: the circled area is lymphatics