Tumor Immunity — Flashcards

Flashcard 1: Activating mutation in _____ is responsible for bladder carcinoma.

Answer: HRAS

Flashcard 2: FISH should be performed in all cases of breast tumors with immunohistochemistry (IHC) score of _____+

Answer: 2

Flashcard 3: In breast cancer IHC, a HER2 score of 3+ is interpreted as _____.

Answer: Positive

Flashcard 4: What is the chromosomal translocation that results in malignancy from the **ABL** oncogene? _____

Answer: t(9;22)

Flashcard 5: IHC score is said to be 2+ if the breast cancer is HER2 _____

Answer: equivocal

Flashcard 6: Tumor cells with multilobulated nuclei (“cloverleaf” or “flower” cells) which is characteristic of _____ Leukemia/Lymphoma.

Answer: Adult T-Cell

Flashcard 7: The following image represents the _____ carcinoma subtype of invasive ductal carcinoma (breast): hint: the circled area is lymphatics

Answer: inflammatory

Flashcard 8: In HPV-_____ SCC of the oral cavity, patients generally present with large primary lesions with variable nodal disease.

Answer: negative

Flashcard 9: What type of rhabdomyosarcoma is shown in the given image? _____ **most common subtype

Answer: Embryonal

Flashcard 10: In the TNM classification of laryngeal carcinoma, stage **T3** is defined by _____.

Answer: vocal cord fixation

Extra: TNM Staging for Glottic Laryngeal Cancer: - T1: Limited to vocal cord(s); normal mobility. - T2: Extension to supraglottis/subglottis; impaired mobility. - T3: Vocal cord fixation. - T4a: Invasion through thyroid cartilage or into extralaryngeal tissues.