Tumor Progression and Metastasis — Flashcards

Flashcard 1: Borderline tumors have _____ prognosis than clearly malignant tumors, but still carry metastatic potential

Answer: better

Flashcard 2: To remember the most common neoplasias that spread _____Embryonal carcinomaHepatocellular carcinomaSarcomaChoriocarcinomaRenal cell carcinomaFollicular carcinoma of the thyroid

Answer: hematogenously (Every Hematogenous Spreading Cancer Reigns Foolishly)

Flashcard 3: What is the most common visceral organ involved in metastatic spread of neoplasms?

Answer: Liver

Extra: The most common **site** of metastasis overall is the **lymph nodes**. The most common **visceral organ** involved in distant (hematogenous) metastasis is the **liver**, followed by the **lungs**. *Note: The liver is frequently involved because it receives blood from both the systemic circulation and the portal system.*

Flashcard 4: E-cadherin overexpression is a hallmark of _____ breast carcinoma

Answer: inflammatory

Flashcard 5: The most common primary sites for bone metastasis when the primary is unknown are _____.

Answer: Lung cancer and kidney cancer

Flashcard 6: Tumor staging is based on _____ (c) or pathological (p) findings

Answer: clinical

Flashcard 7: Invasive carcinomas become metastatic when they invade the _____ or blood

Answer: lymphatics

Flashcard 8: Tumor cells can attach to _____ and destroy the basement membrane (type IV collagen) via collagenase

Answer: laminin

Flashcard 9: The following image represents the _____ carcinoma subtype of invasive ductal carcinoma (breast): hint: the circled area is lymphatics

Answer: inflammatory

Flashcard 10: In HPV-_____ SCC of the oral cavity, patients generally present with large primary lesions with variable nodal disease.

Answer: negative