Neoplasia — Flashcards

Flashcard 221: What is the most common visceral organ involved in metastatic spread of neoplasms?

Answer: Liver

Extra: The most common **site** of metastasis overall is the **lymph nodes**. The most common **visceral organ** involved in distant (hematogenous) metastasis is the **liver**, followed by the **lungs**. *Note: The liver is frequently involved because it receives blood from both the systemic circulation and the portal system.*

Flashcard 222: Retinoblastoma is composed of small _____philic cells (retinoblasts), with large hyperchromatic nuclei and scanty cytoplasm.

Answer: baso

Flashcard 223: _____ refers to a lack of differentiation.

Answer: Anaplasia

Flashcard 224: The suffix -oma attached to a cell type from which a tumor originates is suggestive of a benign _____ tumor.

Answer: mesenchymal

Flashcard 225: The most common site of rhabdomyosarcoma in adults is _____

Answer: Extremities (typically Pleomorphic variant)

Extra: In adults, rhabdomyosarcoma is rare and most commonly presents as the **pleomorphic variant**, which primarily involves the deep soft tissues of the **extremities**. In contrast, rhabdomyosarcoma in **children** most commonly occurs in the **head and neck** region, followed by the genitourinary tract.

Flashcard 226: Extragonadal germ cell tumor is most commonly seen in _____.

Answer: mediastinum

Flashcard 227: The most important determinant of prognosis in Wilm's tumor is its _____

Answer: histology

Flashcard 228: The most important determinant of prognosis in Wilms tumor is _____.

Answer: histology

Flashcard 229: What type of rhabdomyosarcoma carries the worst prognosis?_____

Answer: Pleomorphic

Flashcard 230: Lung metastasis is more common in _____ thyroid carcinoma.

Answer: Follicular and Anaplastic